Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution

Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo, Kazuhiro Ichikawa

    Research output: Contribution to journalArticle

    Abstract

    In hyperpolarization of 13C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the 13C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of 13C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different 13C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized 13C was barely affected by the use of a Gd complex that displays repulsive interaction with the 13C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.

    Original languageEnglish
    Pages (from-to)157-160
    Number of pages4
    JournalJournal of Magnetic Resonance
    Volume270
    DOIs
    Publication statusPublished - Sep 1 2016

    Fingerprint

    Gadolinium
    Magnetic resonance
    gadolinium
    Contrast Media
    magnetic resonance
    dissolving
    Dissolution
    Magnetic Resonance Spectroscopy
    life (durability)
    probes
    interactions
    Electric charge
    Spin-lattice relaxation
    electric charge
    spin-lattice relaxation
    nuclear spin
    Relaxation time
    attraction
    relaxation time
    Polarization

    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Nuclear and High Energy Physics
    • Condensed Matter Physics

    Cite this

    Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution. / Takakusagi, Yoichi; Inoue, Kaori; Naganuma, Tatsuya; Hyodo, Fuminori; Ichikawa, Kazuhiro.

    In: Journal of Magnetic Resonance, Vol. 270, 01.09.2016, p. 157-160.

    Research output: Contribution to journalArticle

    Takakusagi, Yoichi ; Inoue, Kaori ; Naganuma, Tatsuya ; Hyodo, Fuminori ; Ichikawa, Kazuhiro. / Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution. In: Journal of Magnetic Resonance. 2016 ; Vol. 270. pp. 157-160.
    @article{d4423165f8b1406f8bd2b0f8fe43d2f3,
    title = "Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution",
    abstract = "In hyperpolarization of 13C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the 13C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of 13C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different 13C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized 13C was barely affected by the use of a Gd complex that displays repulsive interaction with the 13C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.",
    author = "Yoichi Takakusagi and Kaori Inoue and Tatsuya Naganuma and Fuminori Hyodo and Kazuhiro Ichikawa",
    year = "2016",
    month = "9",
    day = "1",
    doi = "10.1016/j.jmr.2016.07.015",
    language = "English",
    volume = "270",
    pages = "157--160",
    journal = "Journal of Magnetic Resonance",
    issn = "1090-7807",
    publisher = "Academic Press Inc.",

    }

    TY - JOUR

    T1 - Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution

    AU - Takakusagi, Yoichi

    AU - Inoue, Kaori

    AU - Naganuma, Tatsuya

    AU - Hyodo, Fuminori

    AU - Ichikawa, Kazuhiro

    PY - 2016/9/1

    Y1 - 2016/9/1

    N2 - In hyperpolarization of 13C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the 13C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of 13C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different 13C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized 13C was barely affected by the use of a Gd complex that displays repulsive interaction with the 13C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.

    AB - In hyperpolarization of 13C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the 13C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of 13C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different 13C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized 13C was barely affected by the use of a Gd complex that displays repulsive interaction with the 13C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.

    UR - http://www.scopus.com/inward/record.url?scp=84979939281&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84979939281&partnerID=8YFLogxK

    U2 - 10.1016/j.jmr.2016.07.015

    DO - 10.1016/j.jmr.2016.07.015

    M3 - Article

    AN - SCOPUS:84979939281

    VL - 270

    SP - 157

    EP - 160

    JO - Journal of Magnetic Resonance

    JF - Journal of Magnetic Resonance

    SN - 1090-7807

    ER -