Effect of local anesthetics on the electrical characteristics of an excitable model membrane composed of dioleyl phosphate. I. Static and steady-state response

Satoru Iiyama, Yukio Suezaki, Kiyoshi Toko, Takuya Murata, Hiroshi Kamaya, Issaku Ueda, Kaoru Yamafuji

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The local anesthetics, tetracaine, procaine and lidocaine, interacted with a negatively charged lipid membrane composed of dioleyl phosphate (DOPH), which exhibited a self-sustained oscillation of the membrane potential. The anesthetics depolarized the membrane potential when present in increasing concentrations, whereas they increased the membrane resistance at low concentrations and decreased it at high concentrations. The above results were analyzed on the basis of electrochemical theory taking into account ion flux across the membrane. The electrical characteristics are affected by both the hydrophobicity and the diffusion constant of local anesthetics within the membrane.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalBiophysical Chemistry
Issue number2
Publication statusPublished - Jul 1990


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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