Effect of local anesthetics on the electrical characteristics of an excitable model membrane composed of dioleyl phosphate. II. Dynamic response

Satoru Iiyama, Kiyoshi Toko, Takuya Murata, Yukio Suezaki, Hiroshi Kamaya, Issaku Ueda, Kaoru Yamafuji

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The effects of local anesthetics (tetracaine, procaine and lidocaine) on self-sustained electrical oscillations were studied for a lipid membrane comprising dioleyl phosphate (DOPH). This model membrane exhibits oscillation of the membrane potential in a manner similar to that of nerve membranes, i.e., repetitive firing, in the presence of an ion-concentration gradient, on the application of d.c. electric current. Relatively weak anesthetics such as procaine and lidocaine increased the frequency of self-sustained oscillation, and finally induced aperiodic, rapid oscillation. The strong anesthetic tetracaine inhibited oscillation.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalBiophysical Chemistry
Issue number2
Publication statusPublished - Jul 1990


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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