TY - JOUR
T1 - Effect of local anesthetics on the electrical characteristics of an excitable model membrane composed of dioleyl phosphate. II. Dynamic response
AU - Iiyama, Satoru
AU - Toko, Kiyoshi
AU - Murata, Takuya
AU - Suezaki, Yukio
AU - Kamaya, Hiroshi
AU - Ueda, Issaku
AU - Yamafuji, Kaoru
PY - 1990/7
Y1 - 1990/7
N2 - The effects of local anesthetics (tetracaine, procaine and lidocaine) on self-sustained electrical oscillations were studied for a lipid membrane comprising dioleyl phosphate (DOPH). This model membrane exhibits oscillation of the membrane potential in a manner similar to that of nerve membranes, i.e., repetitive firing, in the presence of an ion-concentration gradient, on the application of d.c. electric current. Relatively weak anesthetics such as procaine and lidocaine increased the frequency of self-sustained oscillation, and finally induced aperiodic, rapid oscillation. The strong anesthetic tetracaine inhibited oscillation.
AB - The effects of local anesthetics (tetracaine, procaine and lidocaine) on self-sustained electrical oscillations were studied for a lipid membrane comprising dioleyl phosphate (DOPH). This model membrane exhibits oscillation of the membrane potential in a manner similar to that of nerve membranes, i.e., repetitive firing, in the presence of an ion-concentration gradient, on the application of d.c. electric current. Relatively weak anesthetics such as procaine and lidocaine increased the frequency of self-sustained oscillation, and finally induced aperiodic, rapid oscillation. The strong anesthetic tetracaine inhibited oscillation.
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U2 - 10.1016/0301-4622(90)85018-2
DO - 10.1016/0301-4622(90)85018-2
M3 - Article
C2 - 17056430
AN - SCOPUS:0025294011
SN - 0301-4622
VL - 36
SP - 149
EP - 154
JO - Biophysical Chemistry
JF - Biophysical Chemistry
IS - 2
ER -