Effect of local chain dynamics on a bioinert interface

Toyoaki Hirata, Hisao Matsuno, Daisuke Kawaguchi, Tomoyasu Hirai, Norifumi L. Yamada, Masaru Tanaka, Keiji Tanaka

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.

Original languageEnglish
Pages (from-to)3661-3667
Number of pages7
JournalLangmuir
Volume31
Issue number12
DOIs
Publication statusPublished - Mar 31 2015

Fingerprint

Water
acrylates
water
Polymers
Platelets
platelets
blood
molecular weight
polymers
adhesion
Blood
Adhesion
Molecular weight
proteins
Proteins
Adsorption
adsorption
Polymethyl Methacrylate
Polymethyl methacrylates
polymethyl methacrylate

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Effect of local chain dynamics on a bioinert interface. / Hirata, Toyoaki; Matsuno, Hisao; Kawaguchi, Daisuke; Hirai, Tomoyasu; Yamada, Norifumi L.; Tanaka, Masaru; Tanaka, Keiji.

In: Langmuir, Vol. 31, No. 12, 31.03.2015, p. 3661-3667.

Research output: Contribution to journalArticle

Hirata, Toyoaki ; Matsuno, Hisao ; Kawaguchi, Daisuke ; Hirai, Tomoyasu ; Yamada, Norifumi L. ; Tanaka, Masaru ; Tanaka, Keiji. / Effect of local chain dynamics on a bioinert interface. In: Langmuir. 2015 ; Vol. 31, No. 12. pp. 3661-3667.
@article{c6254637266d4759a7fa37de0b822054,
title = "Effect of local chain dynamics on a bioinert interface",
abstract = "Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.",
author = "Toyoaki Hirata and Hisao Matsuno and Daisuke Kawaguchi and Tomoyasu Hirai and Yamada, {Norifumi L.} and Masaru Tanaka and Keiji Tanaka",
year = "2015",
month = "3",
day = "31",
doi = "10.1021/acs.langmuir.5b00258",
language = "English",
volume = "31",
pages = "3661--3667",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Effect of local chain dynamics on a bioinert interface

AU - Hirata, Toyoaki

AU - Matsuno, Hisao

AU - Kawaguchi, Daisuke

AU - Hirai, Tomoyasu

AU - Yamada, Norifumi L.

AU - Tanaka, Masaru

AU - Tanaka, Keiji

PY - 2015/3/31

Y1 - 2015/3/31

N2 - Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.

AB - Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.

UR - http://www.scopus.com/inward/record.url?scp=84963949895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963949895&partnerID=8YFLogxK

U2 - 10.1021/acs.langmuir.5b00258

DO - 10.1021/acs.langmuir.5b00258

M3 - Article

C2 - 25760401

AN - SCOPUS:84963949895

VL - 31

SP - 3661

EP - 3667

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 12

ER -