Effect of losartan on serum uric acid in hypertension treated with a diuretic

The COMFORT study

Kiyoshi Matsumura, Hisatomi Arima, Mitsuhiro Tominaga, Toshio Ohtsubo, Toshiyuki Sasaguri, Koji Fujii, Masayo Fukuhara, Keiko Uezono, Yuki Morinaga, Yuko Ohta, Takatoshi Otonari, Junya Kawasaki, Isao Kato, Takuya Tsuchihashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It has been shown that losartan, an angiotensin II receptor blocker (ARB), reduces serum uric acid levels. However, the effects of losartan on serum uric acid levels in the patients treated with a thiazide diuretic have not been fully elucidated. We have investigated the effects of losartan compared with other ARBs on blood variables and blood pressure control in hypertensive patients treated with a thiazide diuretic using data from the COMFORT study. The present analysis included a total of 118 hypertensive subjects on combination treatment with ARBs except for losartan and a diuretic who were randomly assigned to a daily regimen of a combination pill (losartan 50 mg/hydrochlorothiazide 12.5 mg) or to continuation of two pills, an ARB except for losartan and a diuretic. Blood pressures were evaluated at 1, 3, and 6 months after randomization and changes in blood variables including serum uric acid were evaluated during 6 months treatment period. Mean follow-up blood pressure levels were not different between the combination pill (losartan treatment) group and the control (ARBs except for losartan) group. On the other hand, serum uric acid significantly decreased in the combination pill group compared with the control group (-0.44 versus + 0.10 mg/dl; p=0.01), although hematocrit, serum creatinine, sodium and potassium were not different between the groups. These results suggest that the treatment regimen switched from a combination therapy of ARBs except for losartan and a diuretic to a combination pill (losartan/ hydrochlorothiazide) decreases serum uric acid without affecting blood pressure control.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalClinical and Experimental Hypertension
Volume37
Issue number3
DOIs
Publication statusPublished - Apr 1 2015

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Losartan
Uric Acid
Diuretics
Hypertension
Serum
Blood Pressure
Sodium Chloride Symporter Inhibitors
Angiotensin Receptor Antagonists
Therapeutics
Control Groups
Hydrochlorothiazide
Random Allocation
Hematocrit
Creatinine
Potassium
Sodium

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

Cite this

Effect of losartan on serum uric acid in hypertension treated with a diuretic : The COMFORT study. / Matsumura, Kiyoshi; Arima, Hisatomi; Tominaga, Mitsuhiro; Ohtsubo, Toshio; Sasaguri, Toshiyuki; Fujii, Koji; Fukuhara, Masayo; Uezono, Keiko; Morinaga, Yuki; Ohta, Yuko; Otonari, Takatoshi; Kawasaki, Junya; Kato, Isao; Tsuchihashi, Takuya.

In: Clinical and Experimental Hypertension, Vol. 37, No. 3, 01.04.2015, p. 192-196.

Research output: Contribution to journalArticle

Matsumura, K, Arima, H, Tominaga, M, Ohtsubo, T, Sasaguri, T, Fujii, K, Fukuhara, M, Uezono, K, Morinaga, Y, Ohta, Y, Otonari, T, Kawasaki, J, Kato, I & Tsuchihashi, T 2015, 'Effect of losartan on serum uric acid in hypertension treated with a diuretic: The COMFORT study', Clinical and Experimental Hypertension, vol. 37, no. 3, pp. 192-196. https://doi.org/10.3109/10641963.2014.933968
Matsumura, Kiyoshi ; Arima, Hisatomi ; Tominaga, Mitsuhiro ; Ohtsubo, Toshio ; Sasaguri, Toshiyuki ; Fujii, Koji ; Fukuhara, Masayo ; Uezono, Keiko ; Morinaga, Yuki ; Ohta, Yuko ; Otonari, Takatoshi ; Kawasaki, Junya ; Kato, Isao ; Tsuchihashi, Takuya. / Effect of losartan on serum uric acid in hypertension treated with a diuretic : The COMFORT study. In: Clinical and Experimental Hypertension. 2015 ; Vol. 37, No. 3. pp. 192-196.
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