Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

Keisuke Tsuge, Yayoi Watanabe, Norihide Maeda, Shin Ichi Abe, Toru Tsuruhashi, Takashi Yoshimura, Masahiro Yoshiki, Hirofumi Tachibana, Koji Yamada

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Abstract

The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume54
Issue number5
DOIs
Publication statusPublished - Aug 1 2007

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All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Tsuge, K., Watanabe, Y., Maeda, N., Abe, S. I., Tsuruhashi, T., Yoshimura, T., ... Yamada, K. (2007). Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation. Nippon Shokuhin Kagaku Kogaku Kaishi, 54(5), 241-246. https://doi.org/10.3136/nskkk.54.241