Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

Keisuke Tsuge; Yayoi Watanabe; Norihide Maeda; Shin Ichi Abe; Toru Tsuruhashi; Takashi Yoshimura; Masahiro Yoshiki; Hirofumi Tachibana; Koji Yamada

doi:10.3136/nskkk.54.241

Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

Keisuke Tsuge, Yayoi Watanabe, Norihide Maeda, Shin Ichi Abe, Toru Tsuruhashi, Takashi Yoshimura, Masahiro Yoshiki, Hirofumi Tachibana, Koji Yamada

Food Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	Nippon Shokuhin Kagaku Kogaku Kaishi
Volume	54
Issue number	5
DOIs	https://doi.org/10.3136/nskkk.54.241
Publication status	Published - Aug 1 2007

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Food Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3136/nskkk.54.241

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title = "Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation",

abstract = "The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.",

author = "Keisuke Tsuge and Yayoi Watanabe and Norihide Maeda and Abe, {Shin Ichi} and Toru Tsuruhashi and Takashi Yoshimura and Masahiro Yoshiki and Hirofumi Tachibana and Koji Yamada",

year = "2007",

month = aug,

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doi = "10.3136/nskkk.54.241",

language = "English",

volume = "54",

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T1 - Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

AU - Tsuge, Keisuke

AU - Watanabe, Yayoi

AU - Maeda, Norihide

AU - Abe, Shin Ichi

AU - Tsuruhashi, Toru

AU - Yoshimura, Takashi

AU - Yoshiki, Masahiro

AU - Tachibana, Hirofumi

AU - Yamada, Koji

PY - 2007/8/1

Y1 - 2007/8/1

N2 - The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.

AB - The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.

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Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

Abstract

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