Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: A randomized, open-label pilot study

Kosaku Iha, Nao Suzuki, Masahiro Yoneda, Toru Takeshita, Takao Hirofuji

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim The aim of the study was to evaluate the effect of mouth cleaning with hinokitiol-containing gel on oral malodor. Methods An open-label, randomized, controlled trial was conducted to assess oral malodor and clinical parameters related to oral malodor before and after mouth cleaning with hinokitiol-containing gel (n = 9) or with gel not including hinokitiol (n = 9). Mouth cleaning included the teeth, gingiva, and tongue and was carried out 3 times per day for 4 weeks. Results Organoleptic test (OLT) scores (P =.021), levels of hydrogen sulfide (P =.008) and methyl mercaptan (P =.020), frequency of bleeding on probing, average probing pocket depth, and plaque index significantly improved in the group using hinokitiol. In contrast, only the OLT score (P =.031) significantly improved in the control group after the treatment regimen. Conclusion Mouth cleaning with hinokitiol-containing gel may be effective for reduction of oral malodor.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume116
Issue number4
DOIs
Publication statusPublished - Oct 1 2013

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Mouth
Gels
Hydrogen Sulfide
Gingiva
Tongue
Sulfhydryl Compounds
Tooth
Randomized Controlled Trials
beta-thujaplicin
Hemorrhage
Control Groups
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Effect of mouth cleaning with hinokitiol-containing gel on oral malodor : A randomized, open-label pilot study. / Iha, Kosaku; Suzuki, Nao; Yoneda, Masahiro; Takeshita, Toru; Hirofuji, Takao.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 116, No. 4, 01.10.2013, p. 433-439.

Research output: Contribution to journalArticle

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AU - Yoneda, Masahiro

AU - Takeshita, Toru

AU - Hirofuji, Takao

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N2 - Aim The aim of the study was to evaluate the effect of mouth cleaning with hinokitiol-containing gel on oral malodor. Methods An open-label, randomized, controlled trial was conducted to assess oral malodor and clinical parameters related to oral malodor before and after mouth cleaning with hinokitiol-containing gel (n = 9) or with gel not including hinokitiol (n = 9). Mouth cleaning included the teeth, gingiva, and tongue and was carried out 3 times per day for 4 weeks. Results Organoleptic test (OLT) scores (P =.021), levels of hydrogen sulfide (P =.008) and methyl mercaptan (P =.020), frequency of bleeding on probing, average probing pocket depth, and plaque index significantly improved in the group using hinokitiol. In contrast, only the OLT score (P =.031) significantly improved in the control group after the treatment regimen. Conclusion Mouth cleaning with hinokitiol-containing gel may be effective for reduction of oral malodor.

AB - Aim The aim of the study was to evaluate the effect of mouth cleaning with hinokitiol-containing gel on oral malodor. Methods An open-label, randomized, controlled trial was conducted to assess oral malodor and clinical parameters related to oral malodor before and after mouth cleaning with hinokitiol-containing gel (n = 9) or with gel not including hinokitiol (n = 9). Mouth cleaning included the teeth, gingiva, and tongue and was carried out 3 times per day for 4 weeks. Results Organoleptic test (OLT) scores (P =.021), levels of hydrogen sulfide (P =.008) and methyl mercaptan (P =.020), frequency of bleeding on probing, average probing pocket depth, and plaque index significantly improved in the group using hinokitiol. In contrast, only the OLT score (P =.031) significantly improved in the control group after the treatment regimen. Conclusion Mouth cleaning with hinokitiol-containing gel may be effective for reduction of oral malodor.

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