Abstract
The aim of the present study was to elucidate the effects of 4 different cardiovascular drugs on blood lactate levels during an intensive graded exercise test in 17 healthy male subjects. In acute studies, iso-sorbide dinitrate and nifedipine were used. In chronic studies, propranolol dihydrochloride and dilazep dihydrochloride were used. Oxygen uptake (Vo2), heart rate, blood pressure and blood lactate were measured at rest and during the final minute of each exercise session. Hemodynamic measurements during submaximum exercise were influenced by all drugs except isosorbide dinitrate. Vo2 during submaximum and maximum exercises remained unchanged by all drug treatments. Blood lactate levels at rest and during submaximum and maximum exercise also did not change significantly. Work load corresponding to blood lactate concentration of 4 mM (W4 mM) and the 1st and 2nd break points of lactic acid (WBPLA1 and WBPLA2) were almost the same in all treatments. It is concluded that the 3 criteria of blood lactate obtained during the graded exercise test are not affected by these drugs in healthy males.
| Original language | English |
|---|---|
| Pages (from-to) | 617-630 |
| Number of pages | 14 |
| Journal | japanese heart journal |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 1988 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Effect of Nifedipine, Dilazep, Dinitrates and Propranolol on Blood Lactate Accumulation during Intensive Graded Exercise Testing in Healthy Young Subjects. / Tanaka, Hiroaki; Shindo, Munehiro; Kumagai, Shuzo; Yoshida, Toyokazu; Mutaguchi, Takashi; Moriyama, Yoshihiro; Hiroki, Tadayuki; Arakawa, Kikuo.
In: japanese heart journal, Vol. 29, No. 5, 01.01.1988, p. 617-630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Nifedipine, Dilazep, Dinitrates and Propranolol on Blood Lactate Accumulation during Intensive Graded Exercise Testing in Healthy Young Subjects
AU - Tanaka, Hiroaki
AU - Shindo, Munehiro
AU - Kumagai, Shuzo
AU - Yoshida, Toyokazu
AU - Mutaguchi, Takashi
AU - Moriyama, Yoshihiro
AU - Hiroki, Tadayuki
AU - Arakawa, Kikuo
PY - 1988/1/1
Y1 - 1988/1/1
N2 - The aim of the present study was to elucidate the effects of 4 different cardiovascular drugs on blood lactate levels during an intensive graded exercise test in 17 healthy male subjects. In acute studies, iso-sorbide dinitrate and nifedipine were used. In chronic studies, propranolol dihydrochloride and dilazep dihydrochloride were used. Oxygen uptake (Vo2), heart rate, blood pressure and blood lactate were measured at rest and during the final minute of each exercise session. Hemodynamic measurements during submaximum exercise were influenced by all drugs except isosorbide dinitrate. Vo2 during submaximum and maximum exercises remained unchanged by all drug treatments. Blood lactate levels at rest and during submaximum and maximum exercise also did not change significantly. Work load corresponding to blood lactate concentration of 4 mM (W4 mM) and the 1st and 2nd break points of lactic acid (WBPLA1 and WBPLA2) were almost the same in all treatments. It is concluded that the 3 criteria of blood lactate obtained during the graded exercise test are not affected by these drugs in healthy males.
AB - The aim of the present study was to elucidate the effects of 4 different cardiovascular drugs on blood lactate levels during an intensive graded exercise test in 17 healthy male subjects. In acute studies, iso-sorbide dinitrate and nifedipine were used. In chronic studies, propranolol dihydrochloride and dilazep dihydrochloride were used. Oxygen uptake (Vo2), heart rate, blood pressure and blood lactate were measured at rest and during the final minute of each exercise session. Hemodynamic measurements during submaximum exercise were influenced by all drugs except isosorbide dinitrate. Vo2 during submaximum and maximum exercises remained unchanged by all drug treatments. Blood lactate levels at rest and during submaximum and maximum exercise also did not change significantly. Work load corresponding to blood lactate concentration of 4 mM (W4 mM) and the 1st and 2nd break points of lactic acid (WBPLA1 and WBPLA2) were almost the same in all treatments. It is concluded that the 3 criteria of blood lactate obtained during the graded exercise test are not affected by these drugs in healthy males.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023736157&partnerID=8YFLogxK
U2 - 10.1536/ihj.29.617
DO - 10.1536/ihj.29.617
M3 - Article
C2 - 3221439
AN - SCOPUS:0023736157
VL - 29
SP - 617
EP - 630
JO - International Heart Journal
JF - International Heart Journal
SN - 1349-2365
IS - 5
ER -