Effect of oral administration of L-pipecolic acid on food intake in chicks and mice

Tomo Takagi, Ryuichi Ando, Atsushi Ohgushi, Tomonori Nakanishi, Hazizul Hussain-Yusuf, Ryoji Onodera, Hiroyuki Sato, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

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Abstract

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the brain, is involved in the functioning of the γ-aminobutyric acid-ergic system. Previous study has shown that intracerebroventricular injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks. The present study examines whether the action of L-PA was induced by gavage in both chicks and mice. Oral administration of L-PA significantly inhibited food intake at 2 h after treatment in neonatal chicks, although no significant effect of L-Lys was detected. In mice, oral L-PA suppressed food intake compared to the control after 2 h of treatment. It was concluded that L-PA was effective for suppression of food intake after oral administration in both avian and mammalian species.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalAnimal Science Journal
Volume74
Issue number2
DOIs
Publication statusPublished - Apr 1 2003

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pipecolic acid
oral administration
Oral Administration
food intake
Eating
chicks
mice
Aminobutyrates
sleep
Lysine
mouth
lysine
Sleep
injection
brain
Injections
acids
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Effect of oral administration of L-pipecolic acid on food intake in chicks and mice. / Takagi, Tomo; Ando, Ryuichi; Ohgushi, Atsushi; Nakanishi, Tomonori; Hussain-Yusuf, Hazizul; Onodera, Ryoji; Sato, Hiroyuki; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Animal Science Journal, Vol. 74, No. 2, 01.04.2003, p. 101-104.

Research output: Contribution to journalArticle

Takagi, T, Ando, R, Ohgushi, A, Nakanishi, T, Hussain-Yusuf, H, Onodera, R, Sato, H, Denbow, DM & Furuse, M 2003, 'Effect of oral administration of L-pipecolic acid on food intake in chicks and mice', Animal Science Journal, vol. 74, no. 2, pp. 101-104. https://doi.org/10.1046/j.1344-3941.2003.00093.x
Takagi T, Ando R, Ohgushi A, Nakanishi T, Hussain-Yusuf H, Onodera R et al. Effect of oral administration of L-pipecolic acid on food intake in chicks and mice. Animal Science Journal. 2003 Apr 1;74(2):101-104. https://doi.org/10.1046/j.1344-3941.2003.00093.x
Takagi, Tomo ; Ando, Ryuichi ; Ohgushi, Atsushi ; Nakanishi, Tomonori ; Hussain-Yusuf, Hazizul ; Onodera, Ryoji ; Sato, Hiroyuki ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Effect of oral administration of L-pipecolic acid on food intake in chicks and mice. In: Animal Science Journal. 2003 ; Vol. 74, No. 2. pp. 101-104.
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