Effect of oral administration of L-pipecolic acid on food intake in chicks and mice

Tomo Takagi, Ryuichi Ando, Atsushi Ohgushi, Tomonori Nakanishi, Hazizul Hussain-Yusuf, Ryoji Onodera, Hiroyuki Sato, D. Michael Denbow, Mitsuhiro Furuse

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1 Citation (Scopus)

Abstract

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the brain, is involved in the functioning of the γ-aminobutyric acid-ergic system. Previous study has shown that intracerebroventricular injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks. The present study examines whether the action of L-PA was induced by gavage in both chicks and mice. Oral administration of L-PA significantly inhibited food intake at 2 h after treatment in neonatal chicks, although no significant effect of L-Lys was detected. In mice, oral L-PA suppressed food intake compared to the control after 2 h of treatment. It was concluded that L-PA was effective for suppression of food intake after oral administration in both avian and mammalian species.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalAnimal Science Journal
Volume74
Issue number2
DOIs
Publication statusPublished - Apr 1 2003

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

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