Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Y. Yonezawa; H. Hondo; K. Hashimoto; T. Matsumoto; M. Hirano; H. Uchimura; T. Kuroki

doi:10.1007/BF01277028

Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Y. Yonezawa, H. Hondo, K. Hashimoto, T. Matsumoto, M. Hirano, H. Uchimura, T. Kuroki

Clinical Psychology Practice

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K⁺-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

Original language	English
Pages (from-to)	235-240
Number of pages	6
Journal	Journal of Neural Transmission
Volume	94
Issue number	3
DOIs	https://doi.org/10.1007/BF01277028
Publication status	Published - Oct 1993

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/BF01277028

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abstract = "The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.",

author = "Y. Yonezawa and H. Hondo and K. Hashimoto and T. Matsumoto and M. Hirano and H. Uchimura and T. Kuroki",

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AU - Yonezawa, Y.

AU - Hondo, H.

AU - Hashimoto, K.

AU - Matsumoto, T.

AU - Hirano, M.

AU - Uchimura, H.

AU - Kuroki, T.

PY - 1993/10

Y1 - 1993/10

N2 - The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

AB - The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

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Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Abstract

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