Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Y. Yonezawa, H. Hondo, K. Hashimoto, T. Matsumoto, M. Hirano, H. Uchimura, T. Kuroki

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Abstract

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalJournal of Neural Transmission
Volume94
Issue number3
DOIs
Publication statusPublished - Oct 1 1993

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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