Effect of polychlorinated biphenyls and polychlorinated dibenzofurans on leukocyte in peripheral blood and bronchoalveolar lavage fluid.

Y. Nakanishi, Y. Nomoto, A. Matsuki, R. Kunitake, N. Hara

Research output: Contribution to journalArticle

Abstract

In order to investigate immunological abnormalities induced by polychlorinated biphenyls and polychlorinated dibenzofurans, we have performed bronchoalveolar lavage in the rats given polychlorinated biphenyls and polychlorinated dibenzofurans. We have administrated 5.0 mg of polychlorinated biphenyls or 0.5 mg of polychlorinated dibenzofurans to Sprague-Dawley rats intraperitoneally. Four weeks after the administration, mild necrosis of bronchiolar Clara cells and mild edema associated with chronic inflammatory infiltration in the alveoli were seen in both groups. In the peripheral blood, percentage of T-lymphocyte, helper T-cell and suppressor T-cell decreased significantly both in polychlorinated biphenyls and polychlorinated dibenzofurans given rats. On the other hand, in the bronchoalveolar lavage fluid, percentage of T-cell increased only in polychlorinated dibenzofurans given rats and percentage of suppressor T-cell increased in both groups. O2- release by alveolar macrophage increased significantly both when stimulated with wheat germ lectin and with phorbol myristate acetate. These results indicate that immunological alternation may be different between peripheral blood and respiratory system as one of the target organs of these chemicals. Further examination is needed for the analysis of immunological abnormalities in the target organs of polychlorinated biphenyls and polychlorinated dibenzofurans poisoning.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalFukuoka Acta Medica
Volume86
Issue number5
Publication statusPublished - May 1 1995

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Polychlorinated Biphenyls
Bronchoalveolar Lavage Fluid
Leukocytes
T-Lymphocytes
Wheat Germ Agglutinins
Alveolar Macrophages
Bronchoalveolar Lavage
Tetradecanoylphorbol Acetate
Helper-Inducer T-Lymphocytes
Respiratory System
Poisoning
Sprague Dawley Rats
Polychlorinated Dibenzofurans
Edema
Necrosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Effect of polychlorinated biphenyls and polychlorinated dibenzofurans on leukocyte in peripheral blood and bronchoalveolar lavage fluid. / Nakanishi, Y.; Nomoto, Y.; Matsuki, A.; Kunitake, R.; Hara, N.

In: Fukuoka Acta Medica, Vol. 86, No. 5, 01.05.1995, p. 261-266.

Research output: Contribution to journalArticle

Nakanishi, Y. ; Nomoto, Y. ; Matsuki, A. ; Kunitake, R. ; Hara, N. / Effect of polychlorinated biphenyls and polychlorinated dibenzofurans on leukocyte in peripheral blood and bronchoalveolar lavage fluid. In: Fukuoka Acta Medica. 1995 ; Vol. 86, No. 5. pp. 261-266.
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