Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization.

Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.

Original languageEnglish
Pages (from-to)73-74
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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