Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis

Ahmed E. Allam, Alaa M. Nafady, Toshinori Nakagawa, Naomichi Takemoto, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3′′-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3–8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound 2 showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 μg/mL, respectively. For melanogenesis, compounds 2, 3 and 4 exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity. The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of Vicia faba flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.

Original languageEnglish
Pages (from-to)1920-1925
Number of pages6
JournalNatural Product Research
Volume32
Issue number16
DOIs
Publication statusPublished - Aug 18 2018

Fingerprint

melanogenesis
Vicia faba
Polyphenols
Lipase
polyphenols
Bleaching Agents
Skin Lightening Preparations
Melanins
Phytochemicals
Glycosides
Galactose
Flavonoids
Methanol
kaempferol
Skin
flowers
Fabaceae
Melanoma
melanin
melanoma

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis. / Allam, Ahmed E.; Nafady, Alaa M.; Nakagawa, Toshinori; Takemoto, Naomichi; Shimizu, Kuniyoshi.

In: Natural Product Research, Vol. 32, No. 16, 18.08.2018, p. 1920-1925.

Research output: Contribution to journalArticle

Allam, Ahmed E. ; Nafady, Alaa M. ; Nakagawa, Toshinori ; Takemoto, Naomichi ; Shimizu, Kuniyoshi. / Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis. In: Natural Product Research. 2018 ; Vol. 32, No. 16. pp. 1920-1925.
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