Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea

Takashi Kimitsuki, Mitsuru Ohashi, Yoshihiro Umeno, Takamasa Yoshida, Noritaka Komune, teppei noda, Shizuo Komune

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (I K,f), but did not affect the inward current (I K,n). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalNeuroscience Letters
Volume504
Issue number1
DOIs
Publication statusPublished - Oct 17 2011

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Inner Auditory Hair Cells
Salicylates
Cochlea
Potassium
Guinea Pigs
Tinnitus
Hearing Loss
Anti-Inflammatory Agents
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea. / Kimitsuki, Takashi; Ohashi, Mitsuru; Umeno, Yoshihiro; Yoshida, Takamasa; Komune, Noritaka; noda, teppei; Komune, Shizuo.

In: Neuroscience Letters, Vol. 504, No. 1, 17.10.2011, p. 28-31.

Research output: Contribution to journalArticle

Kimitsuki, Takashi ; Ohashi, Mitsuru ; Umeno, Yoshihiro ; Yoshida, Takamasa ; Komune, Noritaka ; noda, teppei ; Komune, Shizuo. / Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea. In: Neuroscience Letters. 2011 ; Vol. 504, No. 1. pp. 28-31.
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