Effect of sarcopenic obesity on outcomes of living-donor liver transplantation for hepatocellular carcinoma

shinji itoh, Tomoharu Yoshizumi, Koichi Kimura, Hirohisa Okabe, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Ken Shirabe, Akihiro Nishie, Yoshihiko Maehara

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Abstract

Background/Aim: We aimed to evaluate the effect of body composition on the outcome of living-donor liver transplantation (LDLT) in patients with hepatocellular carcinoma (HCC). Patients and Methods: We performed LDLT in 153 patients with HCC and divided the patients into two groups based on skeletal muscle mass-to-visceral fat area ratio (SVR), as assessed by computed tomography (CT) measurement, namely a low-SVR group (n=38) and a notlow SVR group (n=112). We compared surgical outcomes between the two groups. Results: A low SVR was significantly correlated with a higher body mass index and male sex. No differences were found between the two groups in terms of other factors. The patients in the low-SVR group had a significantly poorer prognosis than those in the notlow SVR group in terms of recurrence-free (p=0.01) and overall (p=0.03) survival. The results of the multivariate analysis showed low SVR to be an independent and prognostic indicator for patients with HCC who had undergone LDLT. Conclusion: Pre-transplant body composition measured by CT is a major determinant of prognosis in LDLT for HCC in Japan.

Original languageEnglish
Pages (from-to)3029-3034
Number of pages6
JournalAnticancer Research
Volume36
Issue number6
Publication statusPublished - Jun 1 2016

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Living Donors
Liver Transplantation
Hepatocellular Carcinoma
Obesity
Body Composition
Tomography
Intra-Abdominal Fat
Japan
Skeletal Muscle
Body Mass Index
Multivariate Analysis
Transplants
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Effect of sarcopenic obesity on outcomes of living-donor liver transplantation for hepatocellular carcinoma. / itoh, shinji; Yoshizumi, Tomoharu; Kimura, Koichi; Okabe, Hirohisa; Harimoto, Norifumi; Ikegami, Toru; Uchiyama, Hideaki; Shirabe, Ken; Nishie, Akihiro; Maehara, Yoshihiko.

In: Anticancer Research, Vol. 36, No. 6, 01.06.2016, p. 3029-3034.

Research output: Contribution to journalArticle

itoh, S, Yoshizumi, T, Kimura, K, Okabe, H, Harimoto, N, Ikegami, T, Uchiyama, H, Shirabe, K, Nishie, A & Maehara, Y 2016, 'Effect of sarcopenic obesity on outcomes of living-donor liver transplantation for hepatocellular carcinoma', Anticancer Research, vol. 36, no. 6, pp. 3029-3034.
itoh, shinji ; Yoshizumi, Tomoharu ; Kimura, Koichi ; Okabe, Hirohisa ; Harimoto, Norifumi ; Ikegami, Toru ; Uchiyama, Hideaki ; Shirabe, Ken ; Nishie, Akihiro ; Maehara, Yoshihiko. / Effect of sarcopenic obesity on outcomes of living-donor liver transplantation for hepatocellular carcinoma. In: Anticancer Research. 2016 ; Vol. 36, No. 6. pp. 3029-3034.
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N2 - Background/Aim: We aimed to evaluate the effect of body composition on the outcome of living-donor liver transplantation (LDLT) in patients with hepatocellular carcinoma (HCC). Patients and Methods: We performed LDLT in 153 patients with HCC and divided the patients into two groups based on skeletal muscle mass-to-visceral fat area ratio (SVR), as assessed by computed tomography (CT) measurement, namely a low-SVR group (n=38) and a notlow SVR group (n=112). We compared surgical outcomes between the two groups. Results: A low SVR was significantly correlated with a higher body mass index and male sex. No differences were found between the two groups in terms of other factors. The patients in the low-SVR group had a significantly poorer prognosis than those in the notlow SVR group in terms of recurrence-free (p=0.01) and overall (p=0.03) survival. The results of the multivariate analysis showed low SVR to be an independent and prognostic indicator for patients with HCC who had undergone LDLT. Conclusion: Pre-transplant body composition measured by CT is a major determinant of prognosis in LDLT for HCC in Japan.

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