Effect of serum concentration on Candida biofilm formation on acrylic surfaces

H. Nikawa, H. Nishimura, Seicho Makihira, T. Hamada, S. Sadamori, L. P. Samaranayake

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The biofilm formation of the oral fungal pathogen Candida on denture acrylic strips coated with saliva, serum and, saliva-serum pellicle were examined in vitro using Candida albicans (four isolates), Candida glabrata (three isolates) and Candida tropicalis (three isolates). The degree of biofilm activity varied depending upon both the isolate and the pellicle. Significantly increased biofilm activity on the pellicle (particularly serum)coated strips was observed with three isolates of C. albicans and another of C. glabrata on protein-coated acrylics, with increasing concentration of serum in the pellicle. Similar trends were observed with one isolate of C. albicans and C. glabrata, although the effects of pellicles were not significant. In contrast, with all three isolates of C. tropicalis and a single isolate of C. glabrata, although the biofilm activity on the protein-free control strips was significantly higher than that of saliva- coated strips, the increase in activity of pellicle-admixed biofilm depended upon the serum concentration. Candidal biofilm formation on acrylic surfaces is essentially promoted with increasing concentration of serum in the pellicle. This suggests that inflammation in the oral environment would facilitate fungal colonization on denture acrylic.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalMycoses
Volume43
Issue number3-4
DOIs
Publication statusPublished - Jan 1 2000

Fingerprint

Biofilms
Candida
biofilm
Candida glabrata
saliva
Serum
Candida albicans
Saliva
Candida tropicalis
Dentures
mouth
Proteins
proteins
inflammation
Inflammation
pathogens

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

Nikawa, H., Nishimura, H., Makihira, S., Hamada, T., Sadamori, S., & Samaranayake, L. P. (2000). Effect of serum concentration on Candida biofilm formation on acrylic surfaces. Mycoses, 43(3-4), 139-143. https://doi.org/10.1046/j.1439-0507.2000.00564.x

Effect of serum concentration on Candida biofilm formation on acrylic surfaces. / Nikawa, H.; Nishimura, H.; Makihira, Seicho; Hamada, T.; Sadamori, S.; Samaranayake, L. P.

In: Mycoses, Vol. 43, No. 3-4, 01.01.2000, p. 139-143.

Research output: Contribution to journalArticle

Nikawa, H, Nishimura, H, Makihira, S, Hamada, T, Sadamori, S & Samaranayake, LP 2000, 'Effect of serum concentration on Candida biofilm formation on acrylic surfaces', Mycoses, vol. 43, no. 3-4, pp. 139-143. https://doi.org/10.1046/j.1439-0507.2000.00564.x
Nikawa H, Nishimura H, Makihira S, Hamada T, Sadamori S, Samaranayake LP. Effect of serum concentration on Candida biofilm formation on acrylic surfaces. Mycoses. 2000 Jan 1;43(3-4):139-143. https://doi.org/10.1046/j.1439-0507.2000.00564.x
Nikawa, H. ; Nishimura, H. ; Makihira, Seicho ; Hamada, T. ; Sadamori, S. ; Samaranayake, L. P. / Effect of serum concentration on Candida biofilm formation on acrylic surfaces. In: Mycoses. 2000 ; Vol. 43, No. 3-4. pp. 139-143.
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