Effect of several sweet substances on the electrical characteristics of a dioleyl phosphate-millipore membrane.

Satoru Iiyama; Kiyoshi Toko; Kenshi Hayashi; Kaoru Yamafuji

doi:10.1271/bbb1961.53.675

Effect of several sweet substances on the electrical characteristics of a dioleyl phosphate-millipore membrane.

Satoru Iiyama, Kiyoshi Toko, Kenshi Hayashi, Kaoru Yamafuji

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Abstract

Sweet substances (sucrose, lactose, glucose, fructose, galactose, glycerin and aspartame), excepting Na saccharin, effectively interacted with a negatively-charged lipid membrane of dioleyl phosphate (DOPH). These sweet substances decreased the membrane resistance and depolarized the membrane potential. This response differed from those to bitter, sour and salty substances. Together with the result for transient response, it is suggested that sweet substances could penetrate the lipid membrane. Mono- and disaccharides exerted their effects at a concentration corresponding to the threshold value of taste sensation <i>in vivo</i>. Aspartame, which is about 100-fold sweeter than sucrose, was effective at one-hundredth of this concentration. In addition, the effect of sweet substances on a positively-charged lipid membrane was studied. Changes in the membrane electrical potential and resistance were observed by employing Na saccharin, which had no effect on the DOPH membrane.

Original language	English
Pages (from-to)	675-681
Number of pages	7
Journal	Agricultural and Biological Chemistry
Volume	53
Issue number	3
DOIs	https://doi.org/10.1271/bbb1961.53.675
Publication status	Published - 1989

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title = "Effect of several sweet substances on the electrical characteristics of a dioleyl phosphate-millipore membrane.",

abstract = "Sweet substances (sucrose, lactose, glucose, fructose, galactose, glycerin and aspartame), excepting Na saccharin, effectively interacted with a negatively-charged lipid membrane of dioleyl phosphate (DOPH). These sweet substances decreased the membrane resistance and depolarized the membrane potential. This response differed from those to bitter, sour and salty substances. Together with the result for transient response, it is suggested that sweet substances could penetrate the lipid membrane. Mono- and disaccharides exerted their effects at a concentration corresponding to the threshold value of taste sensation in vivo. Aspartame, which is about 100-fold sweeter than sucrose, was effective at one-hundredth of this concentration. In addition, the effect of sweet substances on a positively-charged lipid membrane was studied. Changes in the membrane electrical potential and resistance were observed by employing Na saccharin, which had no effect on the DOPH membrane.",

author = "Satoru Iiyama and Kiyoshi Toko and Kenshi Hayashi and Kaoru Yamafuji",

year = "1989",

doi = "10.1271/bbb1961.53.675",

language = "English",

volume = "53",

pages = "675--681",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "3",

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T1 - Effect of several sweet substances on the electrical characteristics of a dioleyl phosphate-millipore membrane.

AU - Iiyama, Satoru

AU - Toko, Kiyoshi

AU - Hayashi, Kenshi

AU - Yamafuji, Kaoru

PY - 1989

Y1 - 1989

N2 - Sweet substances (sucrose, lactose, glucose, fructose, galactose, glycerin and aspartame), excepting Na saccharin, effectively interacted with a negatively-charged lipid membrane of dioleyl phosphate (DOPH). These sweet substances decreased the membrane resistance and depolarized the membrane potential. This response differed from those to bitter, sour and salty substances. Together with the result for transient response, it is suggested that sweet substances could penetrate the lipid membrane. Mono- and disaccharides exerted their effects at a concentration corresponding to the threshold value of taste sensation in vivo. Aspartame, which is about 100-fold sweeter than sucrose, was effective at one-hundredth of this concentration. In addition, the effect of sweet substances on a positively-charged lipid membrane was studied. Changes in the membrane electrical potential and resistance were observed by employing Na saccharin, which had no effect on the DOPH membrane.

AB - Sweet substances (sucrose, lactose, glucose, fructose, galactose, glycerin and aspartame), excepting Na saccharin, effectively interacted with a negatively-charged lipid membrane of dioleyl phosphate (DOPH). These sweet substances decreased the membrane resistance and depolarized the membrane potential. This response differed from those to bitter, sour and salty substances. Together with the result for transient response, it is suggested that sweet substances could penetrate the lipid membrane. Mono- and disaccharides exerted their effects at a concentration corresponding to the threshold value of taste sensation in vivo. Aspartame, which is about 100-fold sweeter than sucrose, was effective at one-hundredth of this concentration. In addition, the effect of sweet substances on a positively-charged lipid membrane was studied. Changes in the membrane electrical potential and resistance were observed by employing Na saccharin, which had no effect on the DOPH membrane.

U2 - 10.1271/bbb1961.53.675

DO - 10.1271/bbb1961.53.675

M3 - Article

VL - 53

SP - 675

EP - 681

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 3

ER -