Effect of soft segment chemistry on the biostability of segmented polyurethanes. II. In vitro hydrolytic degradation and lipod sorption

Atsushi Takahara; Robert W. Hergenrother; Arthur J. Coury; Stuart L. Cooper

doi:10.1002/jbm.820260609

Effect of soft segment chemistry on the biostability of segmented polyurethanes. II. In vitro hydrolytic degradation and lipod sorption

Atsushi Takahara, Robert W. Hergenrother, Arthur J. Coury, Stuart L. Cooper

Department of Applied Molecular Chemistry

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A series of segmented polyurethanes (SPUs) with various polyol soft segments was prepared and their hydrolytic degradation and degradation due to lipid sorption was investigated. The hydrolytic degradation of the SPUs was investigated in a papain solution, where it was shown that the SPU based on poly(ethy1eneoxide) (PEO) soft segment was susceptible to hydrolytic degradation. X‐ray photoelectron spectroscopic (XPS) data suggest dissociation of the urethane linkage by enzymatic degradation. Degradation by lipid sorption was observed for the SPU based on a poly(dimethylsi1oxane) (PDMS) soft segment. This is ascribed to the high solubility of lipid in the PDMS segment of the SPU.

Original language	English
Pages (from-to)	801-818
Number of pages	18
Journal	Journal of Biomedical Materials Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1002/jbm.820260609
Publication status	Published - Jun 1992

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

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abstract = "A series of segmented polyurethanes (SPUs) with various polyol soft segments was prepared and their hydrolytic degradation and degradation due to lipid sorption was investigated. The hydrolytic degradation of the SPUs was investigated in a papain solution, where it was shown that the SPU based on poly(ethy1eneoxide) (PEO) soft segment was susceptible to hydrolytic degradation. X‐ray photoelectron spectroscopic (XPS) data suggest dissociation of the urethane linkage by enzymatic degradation. Degradation by lipid sorption was observed for the SPU based on a poly(dimethylsi1oxane) (PDMS) soft segment. This is ascribed to the high solubility of lipid in the PDMS segment of the SPU.",

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AU - Takahara, Atsushi

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AU - Coury, Arthur J.

AU - Cooper, Stuart L.

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AB - A series of segmented polyurethanes (SPUs) with various polyol soft segments was prepared and their hydrolytic degradation and degradation due to lipid sorption was investigated. The hydrolytic degradation of the SPUs was investigated in a papain solution, where it was shown that the SPU based on poly(ethy1eneoxide) (PEO) soft segment was susceptible to hydrolytic degradation. X‐ray photoelectron spectroscopic (XPS) data suggest dissociation of the urethane linkage by enzymatic degradation. Degradation by lipid sorption was observed for the SPU based on a poly(dimethylsi1oxane) (PDMS) soft segment. This is ascribed to the high solubility of lipid in the PDMS segment of the SPU.

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Effect of soft segment chemistry on the biostability of segmented polyurethanes. II. In vitro hydrolytic degradation and lipod sorption

Abstract

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