Effect of solvent granularity on the activity coefficient of macromolecules

Yasuhito Karino, Ryo Akiyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of a solvent on the activity coefficient of a macromolecule in crowding media was investigated using the hard-sphere model. The crowding media comprised solvent molecules and crowding agents, and the activity coefficient of a macromolecule immersed in the media was calculated using the integral equation theory. The dependence of the activity coefficient on the concentration of crowding agent for the explicit-solvent model was completely different from that for the inert-solvent model, which has been adopted in conventional studies of crowding problems. Those results indicate that solvent granularity can play an important role in the description of the activity coefficient of macromolecules.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalChemical Physics Letters
Volume478
Issue number4-6
DOIs
Publication statusPublished - Aug 27 2009

Fingerprint

crowding
Activity coefficients
Macromolecules
macromolecules
coefficients
Integral equations
integral equations
Molecules
molecules

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

Effect of solvent granularity on the activity coefficient of macromolecules. / Karino, Yasuhito; Akiyama, Ryo.

In: Chemical Physics Letters, Vol. 478, No. 4-6, 27.08.2009, p. 180-184.

Research output: Contribution to journalArticle

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