Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice

Y. Yoshikai, S. Miake, T. Matsumoto, K. Nomoto, K. Takeya

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    The delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice whose mononuclear phagocyte system (MPS) was blocked or stimulated. Colloidal carbon or carrageenan was used for the blockade of MPS and Corynebacterium parvum or diethylstilbestrol used for the stimulation. The optimal dose of SRBC for the induction of the delayed footpad reaction was lower in MPS-blocked mice than in non-treated mice, whereas a high dose of SRBC was required for the induction of the strongest delayed footpad reaction in MPS-stimulated mice. These results suggest that non-specific phagocytic function of MPS modulates subsequent immune responses after administration of antigens.

    Original languageEnglish
    Pages (from-to)577-583
    Number of pages7
    JournalImmunology
    Volume38
    Issue number3
    Publication statusPublished - 1979

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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