Effect of strontium doping on bone nodule formation of sol-gel derived bioglass

T. T. Swe, K. A. Shariff, A. F.M. Noor, K. Ishikawa, M. Hasmaliza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bioactive glass (BG) has a broad variety of biomedical applications because of its distinctive ability to bond with bone by exchanging ions in simulated body fluid when implanted inside the body, it has drawn enormous interest. Osteoporosis is a main cause of loss of bone density and that adding strontium (Sr) to the matrix of bioglass stimulates bone formation and also increases bone density and mass. This study concerns sol-gel derived Sr doped bioactive glass (BG) (50.77SiO2-24.12Na2O-(23.39-x)CaO-xSrO-1.72P2O5) in the quaternary (SiO2-Na2O-CaO-P2O5) system (x=0, 3, 5 and 8 mol%).The effect of Sr on bone nodule-like formation was conducted by using Calcified Nodule Staining Kit (Cosmo Bio Co., Ltd) after 28 days culture with MC3T3-E1 osteoblast-like cells (Riken Cell Bank, Tokyo, Japan). In XRD, the amorphous peak is slightly shifted to lower 2?° value after SrO was incorporated into BG. Mineralization staining revealed that the larger area of mineralized nodules was detected on Sr (3) BG than others. These results suggest that BG with SrO 3% is a good candidate for bone tissue engineering with fast bone formation.

Original languageEnglish
Title of host publication3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019
EditorsMariatti Jaafar, Nurulakmal Mohd. Sharif
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420304
DOIs
Publication statusPublished - Sep 21 2020
Event3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019 - Penang, Malaysia
Duration: Oct 31 2019Nov 1 2019

Publication series

NameAIP Conference Proceedings
Volume2267
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019
CountryMalaysia
CityPenang
Period10/31/1911/1/19

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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