Effect of Synthetic Food Colorings on Immunoglobulin Production by Rat Lymphocytes

Yuichiro Kuramoto, Osamu Tsuruta, Hirofumi Tachibana, Michihiro Sugano, Koji Yamada

Research output: Contribution to journalArticle

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Abstract

The effect of 4 azo dyes and 5 non-azo dyes used for food coloring on immunoglobulin (Ig) production by rat spleen and mesenteric lymph node (MLN) lymphocytes was examined. The amounts of IgG and IgM produced by MLN lymphocytes after 72 hr cultivation were the same as those of control culture in the presence of 10-1 and 102μM azo dyes. On the other hand, amaranth inhibited IgE to control level at 103μM while IgE level was 1.5 times higher than control for new coccine and sunset yellow FCF. With regard to non-azo colorings, sodium Cu-chlorophyllin inhibited IgE production by both lymphocytes at the concentrations between 100 and 101μM.Among chlorophyll derivatives, Cu- and Fe-derivatives inhibited IgE production by both lymphocytes.Among Mg-derivatives, chlorophyll-b, having aldehyde group as the constituent, enhanced it by both lymphocytes. These results suggest that minerals and aldehyde in porphyllin ring have an important role in the regulation of IgE production.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume42
Issue number1-2
Publication statusPublished - Dec 1 1997

Fingerprint

imitation foods
food coloring
immunoglobulins
Immunoglobulin E
Immunoglobulins
lymphocytes
Lymphocytes
Food
Azo Compounds
rats
azo dyes
Aldehydes
aldehydes
lymph nodes
Lymph Nodes
chlorophyll
amaranth grain
Chlorophyll
Minerals
Immunoglobulin M

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

Cite this

Effect of Synthetic Food Colorings on Immunoglobulin Production by Rat Lymphocytes. / Kuramoto, Yuichiro; Tsuruta, Osamu; Tachibana, Hirofumi; Sugano, Michihiro; Yamada, Koji.

In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 42, No. 1-2, 01.12.1997, p. 193-201.

Research output: Contribution to journalArticle

Kuramoto, Yuichiro ; Tsuruta, Osamu ; Tachibana, Hirofumi ; Sugano, Michihiro ; Yamada, Koji. / Effect of Synthetic Food Colorings on Immunoglobulin Production by Rat Lymphocytes. In: Journal of the Faculty of Agriculture, Kyushu University. 1997 ; Vol. 42, No. 1-2. pp. 193-201.
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