Abstract
The effect of 4 azo dyes and 5 non-azo dyes used for food coloring on immunoglobulin (Ig) production by rat spleen and mesenteric lymph node (MLN) lymphocytes was examined. The amounts of IgG and IgM produced by MLN lymphocytes after 72 hr cultivation were the same as those of control culture in the presence of 10-1 and 102μM azo dyes. On the other hand, amaranth inhibited IgE to control level at 103μM while IgE level was 1.5 times higher than control for new coccine and sunset yellow FCF. With regard to non-azo colorings, sodium Cu-chlorophyllin inhibited IgE production by both lymphocytes at the concentrations between 100 and 101μM.Among chlorophyll derivatives, Cu- and Fe-derivatives inhibited IgE production by both lymphocytes.Among Mg-derivatives, chlorophyll-b, having aldehyde group as the constituent, enhanced it by both lymphocytes. These results suggest that minerals and aldehyde in porphyllin ring have an important role in the regulation of IgE production.
| Original language | English |
|---|---|
| Pages (from-to) | 193-201 |
| Number of pages | 9 |
| Journal | Journal of the Faculty of Agriculture, Kyushu University |
| Volume | 42 |
| Issue number | 1-2 |
| Publication status | Published - Dec 1 1997 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Agronomy and Crop Science
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Effect of Synthetic Food Colorings on Immunoglobulin Production by Rat Lymphocytes. / Kuramoto, Yuichiro; Tsuruta, Osamu; Tachibana, Hirofumi; Sugano, Michihiro; Yamada, Koji.
In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 42, No. 1-2, 01.12.1997, p. 193-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Synthetic Food Colorings on Immunoglobulin Production by Rat Lymphocytes
AU - Kuramoto, Yuichiro
AU - Tsuruta, Osamu
AU - Tachibana, Hirofumi
AU - Sugano, Michihiro
AU - Yamada, Koji
PY - 1997/12/1
Y1 - 1997/12/1
N2 - The effect of 4 azo dyes and 5 non-azo dyes used for food coloring on immunoglobulin (Ig) production by rat spleen and mesenteric lymph node (MLN) lymphocytes was examined. The amounts of IgG and IgM produced by MLN lymphocytes after 72 hr cultivation were the same as those of control culture in the presence of 10-1 and 102μM azo dyes. On the other hand, amaranth inhibited IgE to control level at 103μM while IgE level was 1.5 times higher than control for new coccine and sunset yellow FCF. With regard to non-azo colorings, sodium Cu-chlorophyllin inhibited IgE production by both lymphocytes at the concentrations between 100 and 101μM.Among chlorophyll derivatives, Cu- and Fe-derivatives inhibited IgE production by both lymphocytes.Among Mg-derivatives, chlorophyll-b, having aldehyde group as the constituent, enhanced it by both lymphocytes. These results suggest that minerals and aldehyde in porphyllin ring have an important role in the regulation of IgE production.
AB - The effect of 4 azo dyes and 5 non-azo dyes used for food coloring on immunoglobulin (Ig) production by rat spleen and mesenteric lymph node (MLN) lymphocytes was examined. The amounts of IgG and IgM produced by MLN lymphocytes after 72 hr cultivation were the same as those of control culture in the presence of 10-1 and 102μM azo dyes. On the other hand, amaranth inhibited IgE to control level at 103μM while IgE level was 1.5 times higher than control for new coccine and sunset yellow FCF. With regard to non-azo colorings, sodium Cu-chlorophyllin inhibited IgE production by both lymphocytes at the concentrations between 100 and 101μM.Among chlorophyll derivatives, Cu- and Fe-derivatives inhibited IgE production by both lymphocytes.Among Mg-derivatives, chlorophyll-b, having aldehyde group as the constituent, enhanced it by both lymphocytes. These results suggest that minerals and aldehyde in porphyllin ring have an important role in the regulation of IgE production.
UR - http://www.scopus.com/inward/record.url?scp=0031329938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031329938&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0031329938
VL - 42
SP - 193
EP - 201
JO - Journal of the Faculty of Agriculture, Kyushu University
JF - Journal of the Faculty of Agriculture, Kyushu University
SN - 0023-6152
IS - 1-2
ER -