Effect of the induced drug-metabolizing enzyme activity on the duration of oxolinic acid in fish

Yuji Oshima, K. Kobayashi, L. Fachrudin, N. Ishida

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

One group of 60 carp (ca 100 g each) were fed with a diet containing polychlorinated biphenyl (PCB) (1 mg PCB/kg body weight/day) for 2 weeks to induce drug-metabolizing enzymes. A second group of 60 carp were fed a PCB-free diet as a control. After pretreatment, oxolinic acid (OA) was administered in feed to PCB-treated and control fish in a single dose of 20 mg OA/kg body weight. The peak concentrations of OA in the blood, liver and muscle of PCB-treated fish were lower than half of those in the control. Furthermore, the duration times of OA in the liver and blood of PCB-treated fish were also shortened compared with those in the control. In another test in vitro with hepatic microsomes, the produced amount of dihydroxy-OA in PCB-treated fish increased more than 30-fold compared with that in controls. These facts suggest that the induction of the drug-metabolizing enzyme activity by pollutants such as PCB, will result in large differences in the duration of drugs in fish, when the drugs accept enzymatic reactions.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalMarine Environmental Research
Volume42
Issue number1-4
DOIs
Publication statusPublished - Jan 1 1996

Fingerprint

oxolinic acid
polychlorinated biphenyls
Enzyme activity
Polychlorinated biphenyls
Fish
enzyme activity
PCB
drug
drugs
duration
Acids
acid
fish
Nutrition
carp
Liver
Blood
blood
diet
liver

All Science Journal Classification (ASJC) codes

  • Oceanography
  • Aquatic Science
  • Pollution

Cite this

Effect of the induced drug-metabolizing enzyme activity on the duration of oxolinic acid in fish. / Oshima, Yuji; Kobayashi, K.; Fachrudin, L.; Ishida, N.

In: Marine Environmental Research, Vol. 42, No. 1-4, 01.01.1996, p. 335-338.

Research output: Contribution to journalArticle

Oshima, Yuji ; Kobayashi, K. ; Fachrudin, L. ; Ishida, N. / Effect of the induced drug-metabolizing enzyme activity on the duration of oxolinic acid in fish. In: Marine Environmental Research. 1996 ; Vol. 42, No. 1-4. pp. 335-338.
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