Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Shinji Tokuda, Toshihiko Fukuda, Yutaro Kobayashi, Mitsuru Tanaka, Toshiro Matsui

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

Original languageEnglish
Pages (from-to)828-830
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number4
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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