Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Shinji Tokuda, Toshihiko Fukuda, Yutaro Kobayashi, Mitsuru Tanaka, Toshiro Matsui

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

Original languageEnglish
Pages (from-to)828-830
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number4
DOIs
Publication statusPublished - Apr 30 2012

Fingerprint

Adenine
Thoracic Aorta
Endothelium
Sprague Dawley Rats
Aorta
Rats
Phenylephrine
Vasodilator Agents

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats. / Tokuda, Shinji; Fukuda, Toshihiko; Kobayashi, Yutaro; Tanaka, Mitsuru; Matsui, Toshiro.

In: Bioscience, Biotechnology and Biochemistry, Vol. 76, No. 4, 30.04.2012, p. 828-830.

Research output: Contribution to journalArticle

@article{88d70c280a9349b09c997d30510aa660,
title = "Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats",
abstract = "Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.",
author = "Shinji Tokuda and Toshihiko Fukuda and Yutaro Kobayashi and Mitsuru Tanaka and Toshiro Matsui",
year = "2012",
month = "4",
day = "30",
doi = "10.1271/bbb.110806",
language = "English",
volume = "76",
pages = "828--830",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "4",

}

TY - JOUR

T1 - Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

AU - Tokuda, Shinji

AU - Fukuda, Toshihiko

AU - Kobayashi, Yutaro

AU - Tanaka, Mitsuru

AU - Matsui, Toshiro

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

AB - Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

UR - http://www.scopus.com/inward/record.url?scp=84860162873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860162873&partnerID=8YFLogxK

U2 - 10.1271/bbb.110806

DO - 10.1271/bbb.110806

M3 - Article

VL - 76

SP - 828

EP - 830

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 4

ER -