Effect of three-dimensional electric field and heat conduction to electrodes on the temperature rise during irreversible electroporation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

The irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix (ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to avoid thermal damage of ECM resulted from the Joule heating within the tissue. A three-dimensional (3-D) analysis was conducted in this study to predict temperature rise during the IRE. The equation of electric field and the heat conduction equation were solved numerically by a finite element method. It was clarified that the highest temperature rise occurred at the base of electrodes adjacent to the insulated surface. The result was significantly different from a two-dimensional (2-D) analysis due to end effects, suggesting that the 3-D analysis is required to determine the optimal condition.

Original languageEnglish
Title of host publicationASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011
PublisherAmerican Society of Mechanical Engineers
ISBN (Print)9780791838921
DOIs
Publication statusPublished - 2011
EventASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 - Honolulu, HI, United States
Duration: Mar 13 2011Mar 17 2011

Publication series

NameASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011

Other

OtherASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011
CountryUnited States
CityHonolulu, HI
Period3/13/113/17/11

All Science Journal Classification (ASJC) codes

  • Energy Engineering and Power Technology

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    Nomura, S., Kurata, K., & Takamatsu, H. (2011). Effect of three-dimensional electric field and heat conduction to electrodes on the temperature rise during irreversible electroporation. In ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 (ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011). American Society of Mechanical Engineers. https://doi.org/10.1115/ajtec2011-44214