Effect of Val-Tyr on degradation of bradykinin and angiotensin I

Eiji Seki, Katsuhiro Osajima, Hiroshi Matsufuji, Toshiro Matsui, Yutaka Osajima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bradykinin was converted rapidly into the fragment 1-8 by kininase I when incubated with human plasma. Kininase II inactivated bradykinin by splitting the Pro7-Phe8 and the Phe5-Ser6 bonds in it. ACE inhibitory peptide Val-Tyr and captopril did not inhibit the conversion of bradykinin in human plasma into the fragments 1-8, 1-7 and 1-5. Bradykinin was converted into the fragments 1-7 and 1-5 by dipeptidyl peptidase activity of ACE. Captopril inhibited degradation of bradykinin by dipeptidyl peptidase activity of ACE, but Val-Tyr did not inhibit.

Original languageEnglish
Pages (from-to)1229-12360
Number of pages11132
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume43
Issue number11
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Food Science

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