Effect of Val-Tyr on degradation of bradykinin and angiotensin I

Eiji Seki, Katsuhiro Osajima, Hiroshi Matsufuji, Toshiro Matsui, Yutaka Osajima

Research output: Contribution to journalArticle

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Abstract

Bradykinin was converted rapidly into the fragment 1-8 by kininase I when incubated with human plasma. Kininase II inactivated bradykinin by splitting the Pro7-Phe8 and the Phe5-Ser6 bonds in it. ACE inhibitory peptide Val-Tyr and captopril did not inhibit the conversion of bradykinin in human plasma into the fragments 1-8, 1-7 and 1-5. Bradykinin was converted into the fragments 1-7 and 1-5 by dipeptidyl peptidase activity of ACE. Captopril inhibited degradation of bradykinin by dipeptidyl peptidase activity of ACE, but Val-Tyr did not inhibit.

Original languageEnglish
Pages (from-to)1229-12360
Number of pages11132
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume43
Issue number11
Publication statusPublished - Dec 1 1996

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valyltyrosine
angiotensin I
bradykinin
Angiotensin I
Bradykinin
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
degradation
peptidases
Captopril
Lysine Carboxypeptidase
Peptidyl-Dipeptidase A
peptides
Peptides

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Seki, E., Osajima, K., Matsufuji, H., Matsui, T., & Osajima, Y. (1996). Effect of Val-Tyr on degradation of bradykinin and angiotensin I. Nippon Shokuhin Kagaku Kogaku Kaishi, 43(11), 1229-12360.

Effect of Val-Tyr on degradation of bradykinin and angiotensin I. / Seki, Eiji; Osajima, Katsuhiro; Matsufuji, Hiroshi; Matsui, Toshiro; Osajima, Yutaka.

In: Nippon Shokuhin Kagaku Kogaku Kaishi, Vol. 43, No. 11, 01.12.1996, p. 1229-12360.

Research output: Contribution to journalArticle

Seki, E, Osajima, K, Matsufuji, H, Matsui, T & Osajima, Y 1996, 'Effect of Val-Tyr on degradation of bradykinin and angiotensin I', Nippon Shokuhin Kagaku Kogaku Kaishi, vol. 43, no. 11, pp. 1229-12360.
Seki E, Osajima K, Matsufuji H, Matsui T, Osajima Y. Effect of Val-Tyr on degradation of bradykinin and angiotensin I. Nippon Shokuhin Kagaku Kogaku Kaishi. 1996 Dec 1;43(11):1229-12360.
Seki, Eiji ; Osajima, Katsuhiro ; Matsufuji, Hiroshi ; Matsui, Toshiro ; Osajima, Yutaka. / Effect of Val-Tyr on degradation of bradykinin and angiotensin I. In: Nippon Shokuhin Kagaku Kogaku Kaishi. 1996 ; Vol. 43, No. 11. pp. 1229-12360.
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