Effect of various insecticides on the larval growth and biogenic amine levels of Tribolium castaneum Herbst

A. Hirashima, T. Nagano, M. Eto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Various insecticides reduced larval growth of the red flour beetle (tribolium castaneum Herbst) and various biogenic amines, including octopamine (OA), dopamine (DA), serotonin (5-HT), epinephrine (E), norepinephrine (NE), their precursors and metabolites in the insects were measured by high-performance liquid chromatography coupled with electrochemical detection. Tyrosine occurred in the highest concentration followed by OA, tryptophan and 3,4-dihydroxymandelic acid (DOMA). Tyramine (a precursor of OA in the biosynthetic pathway), synephrine (N-methyl OA), DA, 5-HT, E, NE and their related substances occurred in extremely low quantities compared with OA. The insects were stressed by various insecticides, which resulted in a dramatic change of biogenic amine levels: the OA levels increased, whereas the levels of other biogenic amines and related substances decreased.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalComparative Biochemistry and Physiology. Part C: Pharmacology
Volume107
Issue number3
DOIs
Publication statusPublished - Mar 1994

All Science Journal Classification (ASJC) codes

  • Toxicology

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