Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia

A. Nogami, Kotaro Takasaki, Kaori Kubota, Kazuko Yamaguchi, Chihiro Kawasaki, Kazuya Nakamura, Risako Fujikawa, Naoki Uchida, Shutaro Katsurabayashi, Kenichi Mishima, Ryoji Nishimura, Michihiro Fujiwara, Katsunori Iwasaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Yokukansan (YKS) is a traditional Japanese herbal medicine, which was reported to improve the behavioral and psychological symptoms of dementia (BPSD). However, the effect of YKS on memory dysfunction remains unknown. In this study, we examined the effect of YKS on impaired spatial memory in rats subjected to repeated cerebral ischemia, a well-established animal model for cerebrovascular dementia. Additionally, we compared the effect of YKS and donepezil (DPZ) on cholinergic dysfunction and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia. Spatial memory, as assessed using the eight-arm radial maze task, was impaired by repeated cerebral ischemia and significantly improved following administration of YKS (100, 300, 1000 mg/kg per day, p.o. for 14 days before and after ischemia treatment. Furthermore, a significant improvement was observed following additional 7-day treatment with YKS (1000 mg/kg per day, p.o.) after ischemia. YKS treatment was comparable to DPZ (10 mg/kg per day, p.o.) after ischemia. Microdialysis studies showed that spontaneous release of acetylcholine (ACh) from the dorsal hippocampus was significantly reduced following repeated cerebral ischemia. However, treatment with YKS or DPZ increased spontaneous ACh release following repeated cerebral ischemia. In contrast, hippocampal apoptosis, which developed after repeated ischemia, was suppressed by YKS, but not by DPZ. Overall, we found that YKS improves spatial memory disturbance via its unique character of having both an increasing effect on ACh release and a neuroprotective effect, which will be useful not only for BPSD but also memory dysfunction in cerebrovascular dementia patients.

Original languageEnglish
Pages (from-to)164-175
Number of pages12
JournalJournal of Traditional Medicines
Volume30
Issue number4
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

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Dementia
Animal Models
Brain Ischemia
Ischemia
Acetylcholine
Behavioral Symptoms
Yi-Gan San
Psychology
Herbal Medicine
Microdialysis
Neuroprotective Agents
Therapeutics
Cholinergic Agents
Hippocampus
Apoptosis
donepezil

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Nogami, A., Takasaki, K., Kubota, K., Yamaguchi, K., Kawasaki, C., Nakamura, K., ... Iwasaki, K. (2013). Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia. Journal of Traditional Medicines, 30(4), 164-175. https://doi.org/10.11339/jtm.30.164

Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia. / Nogami, A.; Takasaki, Kotaro; Kubota, Kaori; Yamaguchi, Kazuko; Kawasaki, Chihiro; Nakamura, Kazuya; Fujikawa, Risako; Uchida, Naoki; Katsurabayashi, Shutaro; Mishima, Kenichi; Nishimura, Ryoji; Fujiwara, Michihiro; Iwasaki, Katsunori.

In: Journal of Traditional Medicines, Vol. 30, No. 4, 01.01.2013, p. 164-175.

Research output: Contribution to journalArticle

Nogami, A, Takasaki, K, Kubota, K, Yamaguchi, K, Kawasaki, C, Nakamura, K, Fujikawa, R, Uchida, N, Katsurabayashi, S, Mishima, K, Nishimura, R, Fujiwara, M & Iwasaki, K 2013, 'Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia', Journal of Traditional Medicines, vol. 30, no. 4, pp. 164-175. https://doi.org/10.11339/jtm.30.164
Nogami A, Takasaki K, Kubota K, Yamaguchi K, Kawasaki C, Nakamura K et al. Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia. Journal of Traditional Medicines. 2013 Jan 1;30(4):164-175. https://doi.org/10.11339/jtm.30.164
Nogami, A. ; Takasaki, Kotaro ; Kubota, Kaori ; Yamaguchi, Kazuko ; Kawasaki, Chihiro ; Nakamura, Kazuya ; Fujikawa, Risako ; Uchida, Naoki ; Katsurabayashi, Shutaro ; Mishima, Kenichi ; Nishimura, Ryoji ; Fujiwara, Michihiro ; Iwasaki, Katsunori. / Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia. In: Journal of Traditional Medicines. 2013 ; Vol. 30, No. 4. pp. 164-175.
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AU - Fujikawa, Risako

AU - Uchida, Naoki

AU - Katsurabayashi, Shutaro

AU - Mishima, Kenichi

AU - Nishimura, Ryoji

AU - Fujiwara, Michihiro

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