Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection

Yasunori Sawayama, Masafumi Tatsukawa, Kensuke Kikuchi, Shinji Maeda, Hachiro Ohnishi, Norihiro Furusyo, Jun Hayashi

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3 Citations (Scopus)

Abstract

To investigate the effect of levofloxacin on carotid atherosclerosis, patients with hypercholesterolemia whose carotid atherosclerosis was not improved by probucol therapy (500 mg/day) for 24 months were enrolled. All patients were seropositive for anti C. pneumoniae IgA and/or IgG. Carotid atherosclerosis was evaluated by ultrasonic measurement of the maximum intima-media thickness (Max-IMT). All subjects were prescribed three courses of levofloxacin (each course, 400 mg/day for 2 weeks, followed by 14 days off drug treatment). At 12 months after combined therapy with probucol and levofloxacin, Max-IMT was significantly decreased compared with the value before treatment (P < 0.01). These results suggest that the combination therapy was effective for improving carotid atherosclerosis in C. pneumoniae-seropositive patients.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Sawayama, Y., Tatsukawa, M., Kikuchi, K., Maeda, S., Ohnishi, H., Furusyo, N., & Hayashi, J. (2007). Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. Journal of Infection and Chemotherapy, 13(2), 92-98. https://doi.org/10.1007/s10156-007-0510-2