Effective weekly paclitaxel administration for gastric cancer with malignant ascites--a case report

Teruyoshi Ishida, Hidehiko Shimokawa, Kouji Kawaguchi, Naohiro Nose, Tohru Ikegami, Hiroyuki Itoh, Akinori Kido, Yukiharu Sasaki, Takahiro Ezaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case in which weekly paclitaxel (TXL) administration was effective for gastric cancer with malignant ascites. TXL (80 mg/m2) was infused over 1 hour after short premedication on an outpatient basis. Administration was continued for 3 weeks followed by 1 week rest. The patient was a 49-year-old woman who suffered from non-resectable gastric cancer, staged intraoperatively as having severe lymph node metastasis and malignant ascites. As an outpatient treatment, she was first treated with 5-fluorouracil combined with high-dose Leucovorin for 4 cycles. However, she complained of abdominal fullness and ascites, and received weekly TXL administration as the second line treatment. The ascites had completely disappeared 3 months after administration. The toxic events were anemia (grade 1) and alopecia (grade 2). No major adverse effects such as hypersensitivity reaction, leukopenia or peripheral neuropathy were observed.

Original languageEnglish
Pages (from-to)1643-1646
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume29
Issue number9
Publication statusPublished - Sep 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Ishida, T., Shimokawa, H., Kawaguchi, K., Nose, N., Ikegami, T., Itoh, H., Kido, A., Sasaki, Y., & Ezaki, T. (2002). Effective weekly paclitaxel administration for gastric cancer with malignant ascites--a case report. Gan to kagaku ryoho. Cancer & chemotherapy, 29(9), 1643-1646.