Effectiveness of nilvadipine in two cases of chronic schizophrenia

KAZUO YAMADA, IYOKO ASHIKARI, KIMIO ONISHI, Shigenobu Kanba, GOHEI YAGI, MASAHIRO ASAI

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Abstract Nilvadipine is a calcium channel inhibitor used commonly for the treatment of cerebrovascular insufficiency. We observed two patients with schizophrenia whose psychiatric symptoms and tardive dyskinesia improved after the addition of nilvadipine to their antipsychotic drug regimen. The total score of the brief psychiatric rating scale (BPRS) in case 1 fell from 56 to 42 after 8 weeks on nilvadipine; while that of case 2 fell from 44 to 32. The total score of the abnormal involuntary movement scale (AIMS) in case 2 decreased from 12 to 7. No adverse effects occurred during treatment. Nilvadipine may thus offer a new approach to the adjunctive treatment of schizophrenia.

Original languageEnglish
Pages (from-to)237-238
Number of pages2
JournalPsychiatry and Clinical Neurosciences
Volume49
Issue number4
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

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nilvadipine
Schizophrenia
Brief Psychiatric Rating Scale
Cerebrovascular Disorders
Calcium Channels
Antipsychotic Agents
Psychiatry
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

YAMADA, KAZUO., ASHIKARI, IYOKO., ONISHI, KIMIO., Kanba, S., YAGI, GOHEI., & ASAI, MASAHIRO. (1995). Effectiveness of nilvadipine in two cases of chronic schizophrenia. Psychiatry and Clinical Neurosciences, 49(4), 237-238. https://doi.org/10.1111/j.1440-1819.1995.tb01891.x

Effectiveness of nilvadipine in two cases of chronic schizophrenia. / YAMADA, KAZUO; ASHIKARI, IYOKO; ONISHI, KIMIO; Kanba, Shigenobu; YAGI, GOHEI; ASAI, MASAHIRO.

In: Psychiatry and Clinical Neurosciences, Vol. 49, No. 4, 01.01.1995, p. 237-238.

Research output: Contribution to journalArticle

YAMADA, KAZUO, ASHIKARI, IYOKO, ONISHI, KIMIO, Kanba, S, YAGI, GOHEI & ASAI, MASAHIRO 1995, 'Effectiveness of nilvadipine in two cases of chronic schizophrenia', Psychiatry and Clinical Neurosciences, vol. 49, no. 4, pp. 237-238. https://doi.org/10.1111/j.1440-1819.1995.tb01891.x
YAMADA KAZUO, ASHIKARI IYOKO, ONISHI KIMIO, Kanba S, YAGI GOHEI, ASAI MASAHIRO. Effectiveness of nilvadipine in two cases of chronic schizophrenia. Psychiatry and Clinical Neurosciences. 1995 Jan 1;49(4):237-238. https://doi.org/10.1111/j.1440-1819.1995.tb01891.x
YAMADA, KAZUO ; ASHIKARI, IYOKO ; ONISHI, KIMIO ; Kanba, Shigenobu ; YAGI, GOHEI ; ASAI, MASAHIRO. / Effectiveness of nilvadipine in two cases of chronic schizophrenia. In: Psychiatry and Clinical Neurosciences. 1995 ; Vol. 49, No. 4. pp. 237-238.
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