Effects of α-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter

Y. Hirooka, A. Takeshita, T. Imaizumi, N. Nakamura, H. Tomoike, M. Nakamura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A previous study has suggested that atrial natriuretic peptide (ANP) alters arterial baroreflex control of lumbar and renal sympathetic nerve activity. To explore these mechanisms, we examined the interrelationship of arterial pressure, afferent aortic nerve activity, and aortic diameter in the rabbits anesthetized with α-chloralose before and after sinoarotic denervation and bilateral vagotomy. Arterial pressure was decreased in stepwise fashion by intravenous infusion of α-human ANP (α-hANP, 0.1-1.0 μg/kg/min) or sodium nitroprusside (SNP, 1-5 μg/kg/min). Both in rabbits with intact baroreceptors and in those with baroreceptors denervated, aortic nerve activity and the aortic diameter decreased during hypotension caused by the infusion of SNP but remained unchanged during hypotension caused by the infusion of α-hANP. In addition, we examined the effects of α-hANP and SNP on the responses of the aortic diameter and aortic nerve activity to rapid changes in arterial pressure caused by intravenous phenylephrine or nitroglycerin. Changes in aortic nerve activity and the aortic diameter in response to rapid changes in arterial pressure caused by phenylephrine or nitroglycerin were not different between the infusion of α-hANP and SNP. These results suggest that aortic nerve activity remains unchanged despite hypotension during the infusion of α-hANP, because α-hANP dilates the aorta. Since the aortic diameter increases, strain of aortic baroreceptors does not decrease. A second suggestion is that α-hANP does not alter aortic baroreceptor responses to changes in arterial pressure caused by phenylephrine or nitroglycerin.

Original languageEnglish
Pages (from-to)987-996
Number of pages10
JournalCirculation research
Volume63
Issue number6
DOIs
Publication statusPublished - Jan 1 1988

Fingerprint

Atrial Natriuretic Factor
Pressoreceptors
Arterial Pressure
Single Nucleotide Polymorphism
Nitroglycerin
Phenylephrine
Hypotension
Rabbits
Chloralose
Baroreflex
Vagotomy
Nitroprusside
Denervation
Intravenous Infusions
Aorta
Kidney

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of α-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter. / Hirooka, Y.; Takeshita, A.; Imaizumi, T.; Nakamura, N.; Tomoike, H.; Nakamura, M.

In: Circulation research, Vol. 63, No. 6, 01.01.1988, p. 987-996.

Research output: Contribution to journalArticle

Hirooka, Y. ; Takeshita, A. ; Imaizumi, T. ; Nakamura, N. ; Tomoike, H. ; Nakamura, M. / Effects of α-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter. In: Circulation research. 1988 ; Vol. 63, No. 6. pp. 987-996.
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