Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial

Ohnaka Keizo, Mizuko Ikeda, Takako Maki, Tomoko Okada, Takao Shimazoe, Masahiro Adachi, Masatoshi Nomura, Ryoichi Takayanagi, Suminori Kono

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective. Observational studies have shown a protective association between coffee consumption and type 2 diabetes mellitus whereas caffeine or caffeinated coffee acutely deteriorates glucose tolerance. We investigated the effects of chronic drinking of instant coffee on glucose and insulin concentrations during a 75 g oral glucose tolerance test. Methods. Overweight men with a mild-to-moderate elevation of fasting plasma glucose were randomly allocated to a 16-week intervention of consuming 5 cups of caffeinated (n = 17) or decaffeinated (n = 15) instant coffee per day or no coffee (n = 13). Results. The caffeinated coffee group showed statistically significant decreases in the 2-hour concentrations and the area under the curve of glucose while neither decaffeinated coffee nor coffee group showed such a change. Waist circumstance decreased in the caffeinated coffee group, increased in the decaffeinated coffee group, and did not change in the noncoffee group (P = 0.002). With adjustment for the change in waist circumference, caffeinated and decaffeinated coffee consumption were associated with a modest decrease in the postload glucose levels. Conclusion. Both caffeinated and decaffeinated coffee may be protective against deterioration of glucose tolerance.

Original languageEnglish
Article number207426
JournalJournal of Nutrition and Metabolism
Volume2012
DOIs
Publication statusPublished - Dec 1 2012

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instant coffee
Coffee
Randomized Controlled Trials
Glucose
glucose
metabolism
glucose tolerance
waist
waist circumference
observational studies
caffeine
drinking
noninsulin-dependent diabetes mellitus
fasting
long term effects
insulin
deterioration
Waist Circumference
Glucose Tolerance Test
Caffeine

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

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Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. / Keizo, Ohnaka; Ikeda, Mizuko; Maki, Takako; Okada, Tomoko; Shimazoe, Takao; Adachi, Masahiro; Nomura, Masatoshi; Takayanagi, Ryoichi; Kono, Suminori.

In: Journal of Nutrition and Metabolism, Vol. 2012, 207426, 01.12.2012.

Research output: Contribution to journalArticle

Keizo, Ohnaka ; Ikeda, Mizuko ; Maki, Takako ; Okada, Tomoko ; Shimazoe, Takao ; Adachi, Masahiro ; Nomura, Masatoshi ; Takayanagi, Ryoichi ; Kono, Suminori. / Effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial. In: Journal of Nutrition and Metabolism. 2012 ; Vol. 2012.
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AU - Shimazoe, Takao

AU - Adachi, Masahiro

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