Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters

T. Tsujiuchi, K. Mizumoto, M. Tsutsumi, A. Denda, T. Amanuma, S. Kondoh, Y. Konishi

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2 Citations (Scopus)

Abstract

Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5% ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalCancer Letters
Volume61
Issue number1
DOIs
Publication statusPublished - Dec 9 1991

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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