Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Akiko Matsumoto, Toshihiro Kawamoto, Fumihiro Mutoh, Toyohi Isse, Tsunehiro Oyama, Kyoko Kitagawa, Keiichi I. Nakayama, Masayoshi Ichiba

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization. Our aim was to determine the consequences of the ALDH2 polymorphism on ethanol-administered liver tissue. Methods Aldh2+/+, +/-, and -/- mice were fed with ethanol solution and standard hard feed for 5 weeks. Results The serum alanine aminotransferase (ALT) level in the Aldh2-/- mice clearly decreased upon ethanol feeding, in contrast to Aldh2+/+ mice, in which the ALT level was unchanged. The levels of malondialdehyde, phospho extracellular signal-regulated kinase 2, and tumor necrosis factor-alpha in the liver tissue all correlated with the ALT level. Conclusion These findings suggest that ethanol intake in the presence of inactive ALDH2 decreases the serum ALT level following a decrease in oxidative stress and tumor necrosis factor-alpha secretion.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalPharmacogenetics and Genomics
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 1 2008

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Aldehyde Dehydrogenase
Knockout Mice
Ethanol
Alanine Transaminase
Liver
Tumor Necrosis Factor-alpha
Acetaldehyde
Mitogen-Activated Protein Kinase 1
Malondialdehyde
Serum
Oxidative Stress
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., ... Ichiba, M. (2008). Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenetics and Genomics, 18(10), 847-852. https://doi.org/10.1097/FPC.0b013e328307a0a9

Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. / Matsumoto, Akiko; Kawamoto, Toshihiro; Mutoh, Fumihiro; Isse, Toyohi; Oyama, Tsunehiro; Kitagawa, Kyoko; Nakayama, Keiichi I.; Ichiba, Masayoshi.

In: Pharmacogenetics and Genomics, Vol. 18, No. 10, 01.10.2008, p. 847-852.

Research output: Contribution to journalArticle

Matsumoto, A, Kawamoto, T, Mutoh, F, Isse, T, Oyama, T, Kitagawa, K, Nakayama, KI & Ichiba, M 2008, 'Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice', Pharmacogenetics and Genomics, vol. 18, no. 10, pp. 847-852. https://doi.org/10.1097/FPC.0b013e328307a0a9
Matsumoto, Akiko ; Kawamoto, Toshihiro ; Mutoh, Fumihiro ; Isse, Toyohi ; Oyama, Tsunehiro ; Kitagawa, Kyoko ; Nakayama, Keiichi I. ; Ichiba, Masayoshi. / Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. In: Pharmacogenetics and Genomics. 2008 ; Vol. 18, No. 10. pp. 847-852.
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