Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Akiko Matsumoto, Toshihiro Kawamoto, Fumihiro Mutoh, Toyohi Isse, Tsunehiro Oyama, Kyoko Kitagawa, Keiichi I. Nakayama, Masayoshi Ichiba

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Objective The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization. Our aim was to determine the consequences of the ALDH2 polymorphism on ethanol-administered liver tissue. Methods Aldh2+/+, +/-, and -/- mice were fed with ethanol solution and standard hard feed for 5 weeks. Results The serum alanine aminotransferase (ALT) level in the Aldh2-/- mice clearly decreased upon ethanol feeding, in contrast to Aldh2+/+ mice, in which the ALT level was unchanged. The levels of malondialdehyde, phospho extracellular signal-regulated kinase 2, and tumor necrosis factor-alpha in the liver tissue all correlated with the ALT level. Conclusion These findings suggest that ethanol intake in the presence of inactive ALDH2 decreases the serum ALT level following a decrease in oxidative stress and tumor necrosis factor-alpha secretion.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalPharmacogenetics and Genomics
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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