TY - JOUR
T1 - Effects of acidic calcium phosphate concentration on mechanical strength of porous calcite fabricated by bridging with dicalcium phosphate dihydrate
AU - Koga, Noriko
AU - Ishikawa, Kunio
AU - Tsuru, Kanji
AU - Takahashi, Ichiro
N1 - Funding Information:
This study was supported in part by the Strategic Promotion of Innovative Research and Development Program ( 15im0502004 ) from the Japan Agency for Medical Research and Development and Grant-in-Aid for Scientific Research from the Japanese Society for Promotion of Science and Research ( 15H05035 ).
Publisher Copyright:
© 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/5/15
Y1 - 2016/5/15
N2 - Porous calcium carbonate (CaCO3) has attracted attention as an artificial bone substitute. We previously reported that interconnected porous calcite block can be fabricated when calcite granules are exposed to acidic calcium phosphate (ACaP) under loading conditions. Dicalcium phosphate dihydrate (DCPD) formed on the surface of the calcite granules caused bridging of the calcite granules with one another and formed an interconnected porous calcite block with DCPD. In this study, the effect of the ACaP concentration on the mechanical strength of the interconnected porous calcite was studied under loading conditions. When the ACaP concentration was increased, the amount of DCPD increased and the compressive strength of the porous calcite increased to approximately 2 MPa. The interconnected porous structure was maintained regardless of the ACaP concentration. No statistically significant difference was observed for the porosity, which was approximately 50%, based on the concentration of ACaP. Therefore, we concluded that the amount of precipitated DCPD can be regulated by the concentration of ACaP solution, and the mechanical strength of the porous calcite can be regulated by the amount of the precipitated DCPD.
AB - Porous calcium carbonate (CaCO3) has attracted attention as an artificial bone substitute. We previously reported that interconnected porous calcite block can be fabricated when calcite granules are exposed to acidic calcium phosphate (ACaP) under loading conditions. Dicalcium phosphate dihydrate (DCPD) formed on the surface of the calcite granules caused bridging of the calcite granules with one another and formed an interconnected porous calcite block with DCPD. In this study, the effect of the ACaP concentration on the mechanical strength of the interconnected porous calcite was studied under loading conditions. When the ACaP concentration was increased, the amount of DCPD increased and the compressive strength of the porous calcite increased to approximately 2 MPa. The interconnected porous structure was maintained regardless of the ACaP concentration. No statistically significant difference was observed for the porosity, which was approximately 50%, based on the concentration of ACaP. Therefore, we concluded that the amount of precipitated DCPD can be regulated by the concentration of ACaP solution, and the mechanical strength of the porous calcite can be regulated by the amount of the precipitated DCPD.
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U2 - 10.1016/j.ceramint.2015.12.017
DO - 10.1016/j.ceramint.2015.12.017
M3 - Article
AN - SCOPUS:84961864397
SN - 0272-8842
VL - 42
SP - 7912
EP - 7917
JO - Ceramics International
JF - Ceramics International
IS - 7
ER -