Effects of added ZnTCP on mechanical and biological properties of apatite cement

K. Ishikawa, Y. Miyamoto, T. Toh, T. Yuasa, A. Ito, M. Nagayama, K. Suzuki

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Effects of added Zn doped β-tricalcium phosphate (ZnTCP) on mechanical and biological properties of apatite cement (AC) was studied. Powder x-ray diffractometer revealed that ZnTCP shows no reactivity with AC. The mechanical strength of AC decreased increasing amounts of added ZnTCP. We observed no effect on the setting time of AC when the amount of ZnTCP was 10% or less. Proliferation of the osteoblastic cells was significantly increased on the surface of AC containing 5% ZnTCP when compared with that containing no ZnTCP. In contrast, proliferation of the cells decreased on the surface of AC containing 10% ZnTCP when compared with that free from ZnTCP; indicating cytotoxity. We concluded therefore, that addition of ZnTCP to AC might be useful to enhance the osteoconductivity of AC when release of Zn2+ can be carefully regulated.

Original languageEnglish
Pages (from-to)785-788
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001
Externally publishedYes
Event13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
Duration: Nov 22 2000Nov 26 2000

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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