Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans

Kensuke Egashira, T. Inou, Yoshitaka Hirooka, H. Kai, M. Sugimachi, S. Suzuki, T. Kuga, Y. Urabe, A. Takeshita

Research output: Contribution to journalArticle

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Abstract

Background. It has been suggested that endothelium-related vasomotion is important in the control of coronary circulation. Our goal was to determine if endothelium-dependent dilation of the coronary vasculature was altered with aging in 18 patients with atypical chest pain (age, 23-70 years) who had angiographically normal coronary arteries and no coronary risk factors. Methods and Results. We infused an endothelium-dependent vasodilator acetylcholine (1, 3, 10, and 30 μg/min) and an endothelium-independent vasodilator papaverine (10 mg) into the left coronary artery. The large coronary diameter was assessed by arteriography, and the increase in coronary blood flow was measured using the intracoronary Doppler catheter technique. Acetylcholine increased coronary blood flow in a dose-dependent manner with no changes in arterial pressure and heart rate. The maximum increase in coronary blood flow evoked by acetylcholine varied widely among patients (increase in coronary blood flow ranged from 200% to 560%) and was correlated significantly with aging (r=-.86, P<.001), whereas the peak coronary blood flow response to papaverine was affected slightly by aging (r=-.44, P=.07). The percent increase in blood flow response to acetylcholine to the response to papaverine correlated with aging (r=-.87, P<.001). The slope of the coronary blood flow response to acetylcholine also correlated significantly with aging. The large epicardial coronary artery response to the low doses of acetylcholine (≤10 μg/min) correlated inversely with aging. Conclusions. The results of this study suggest that endothelium-dependent dilation of coronary arteries evoked by acetylcholine may be decreased with aging in humans.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalCirculation
Volume88
Issue number1
DOIs
Publication statusPublished - Jan 1 1993

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Vasodilation
Acetylcholine
Endothelium
Coronary Vessels
Papaverine
Dilatation
Endothelium-Dependent Relaxing Factors
Coronary Circulation
Chest Pain
Vasodilator Agents
Angiography
Arterial Pressure
Catheters
Heart Rate

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. / Egashira, Kensuke; Inou, T.; Hirooka, Yoshitaka; Kai, H.; Sugimachi, M.; Suzuki, S.; Kuga, T.; Urabe, Y.; Takeshita, A.

In: Circulation, Vol. 88, No. 1, 01.01.1993, p. 77-81.

Research output: Contribution to journalArticle

Egashira, K, Inou, T, Hirooka, Y, Kai, H, Sugimachi, M, Suzuki, S, Kuga, T, Urabe, Y & Takeshita, A 1993, 'Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans', Circulation, vol. 88, no. 1, pp. 77-81. https://doi.org/10.1161/01.CIR.88.1.77
Egashira, Kensuke ; Inou, T. ; Hirooka, Yoshitaka ; Kai, H. ; Sugimachi, M. ; Suzuki, S. ; Kuga, T. ; Urabe, Y. ; Takeshita, A. / Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. In: Circulation. 1993 ; Vol. 88, No. 1. pp. 77-81.
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N2 - Background. It has been suggested that endothelium-related vasomotion is important in the control of coronary circulation. Our goal was to determine if endothelium-dependent dilation of the coronary vasculature was altered with aging in 18 patients with atypical chest pain (age, 23-70 years) who had angiographically normal coronary arteries and no coronary risk factors. Methods and Results. We infused an endothelium-dependent vasodilator acetylcholine (1, 3, 10, and 30 μg/min) and an endothelium-independent vasodilator papaverine (10 mg) into the left coronary artery. The large coronary diameter was assessed by arteriography, and the increase in coronary blood flow was measured using the intracoronary Doppler catheter technique. Acetylcholine increased coronary blood flow in a dose-dependent manner with no changes in arterial pressure and heart rate. The maximum increase in coronary blood flow evoked by acetylcholine varied widely among patients (increase in coronary blood flow ranged from 200% to 560%) and was correlated significantly with aging (r=-.86, P<.001), whereas the peak coronary blood flow response to papaverine was affected slightly by aging (r=-.44, P=.07). The percent increase in blood flow response to acetylcholine to the response to papaverine correlated with aging (r=-.87, P<.001). The slope of the coronary blood flow response to acetylcholine also correlated significantly with aging. The large epicardial coronary artery response to the low doses of acetylcholine (≤10 μg/min) correlated inversely with aging. Conclusions. The results of this study suggest that endothelium-dependent dilation of coronary arteries evoked by acetylcholine may be decreased with aging in humans.

AB - Background. It has been suggested that endothelium-related vasomotion is important in the control of coronary circulation. Our goal was to determine if endothelium-dependent dilation of the coronary vasculature was altered with aging in 18 patients with atypical chest pain (age, 23-70 years) who had angiographically normal coronary arteries and no coronary risk factors. Methods and Results. We infused an endothelium-dependent vasodilator acetylcholine (1, 3, 10, and 30 μg/min) and an endothelium-independent vasodilator papaverine (10 mg) into the left coronary artery. The large coronary diameter was assessed by arteriography, and the increase in coronary blood flow was measured using the intracoronary Doppler catheter technique. Acetylcholine increased coronary blood flow in a dose-dependent manner with no changes in arterial pressure and heart rate. The maximum increase in coronary blood flow evoked by acetylcholine varied widely among patients (increase in coronary blood flow ranged from 200% to 560%) and was correlated significantly with aging (r=-.86, P<.001), whereas the peak coronary blood flow response to papaverine was affected slightly by aging (r=-.44, P=.07). The percent increase in blood flow response to acetylcholine to the response to papaverine correlated with aging (r=-.87, P<.001). The slope of the coronary blood flow response to acetylcholine also correlated significantly with aging. The large epicardial coronary artery response to the low doses of acetylcholine (≤10 μg/min) correlated inversely with aging. Conclusions. The results of this study suggest that endothelium-dependent dilation of coronary arteries evoked by acetylcholine may be decreased with aging in humans.

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