Effects of antagonists on N-methyl-d-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat

Takashi Nakagawa, Tetsuya Shirasaki, Narito Tateishi, Kazuyuki Murase, Norio Akaike

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23 Citations (Scopus)

Abstract

The effect of antagonists on N-methyl-d-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional patch-clamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steadystate component. The competitive antagonists of NMDA receptor, d-2-amino-5-phosphonovalerate (APV), d-2-amino-4-phosphonoheptanoate (APH) and 3-3(2-carboxypiperazine-4-yl)propyl-1-phosphate (CPP), selectively suppressed the initial peak of NMDA-induced current more than the steady-state component at low concentrations. The non-competitive antagonists, MK-801, ketamine, Zn2+ and Mg2+, equally blocked both peak and steady-state components.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalNeuroscience Letters
Volume113
Issue number2
DOIs
Publication statusPublished - May 31 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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