Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects

Eiichirou Sugimori, Satoru Shintani, Kunio Ishikawa, Hiroyuiki Hamakawa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The objective of this study was to investigate the regenerative effects of apatite foam (AF) combined with platelet-rich plasma (PRP) on bone defects. Critical-sized defects in the tibia of rats were filled with randomly distributed combinations of AF with and without PRP. The animals were killed after three, six, and 12 weeks, and their tissue responses were histologically examined. At three weeks, we found no significant differences in bone regeneration against control group (21.9±3.1%) when PRP (20.3±4.2%) and AF (21.6±2.9%) were used independently of each other. In contrast, significantly (p<0.01) larger amount of bone (32.3±6.5%) was formed when the defect was filled with PRP-incorporated AF. At six weeks, both PRP (38.1±3.2%) and AF (39.6±7.8%) showed significantly (p<0.05) higher rates of bone regeneration than the control, even though they were used independently. Moreover, the amount of regenerated bone significantly (p<0.01) increased in the defect filled with PRP-incorporated AF (76.1±8.2%). We concluded, therefore, that the combination of PRP and AF may be useful for the regeneration of defected bone.

Original languageEnglish
Pages (from-to)591-596
Number of pages6
JournalDental Materials Journal
Volume25
Issue number3
DOIs
Publication statusPublished - Dec 15 2006

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Apatites
Bone Regeneration
Platelet-Rich Plasma
Apatite
Platelets
Foams
Bone
Plasmas
Defects
Bone and Bones
Tibia
Rats
Animals
Tissue
Control Groups

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Biomaterials

Cite this

Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects. / Sugimori, Eiichirou; Shintani, Satoru; Ishikawa, Kunio; Hamakawa, Hiroyuiki.

In: Dental Materials Journal, Vol. 25, No. 3, 15.12.2006, p. 591-596.

Research output: Contribution to journalArticle

Sugimori, Eiichirou ; Shintani, Satoru ; Ishikawa, Kunio ; Hamakawa, Hiroyuiki. / Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects. In: Dental Materials Journal. 2006 ; Vol. 25, No. 3. pp. 591-596.
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