Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats

Tatsuo Nakahara, Toshihide Kuroki, Hisao Hondo, Tetsuyuki Tsutsumi, Kenji Fukuda, Hiroshi Yao, Hideyuki Uchimura

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19 Citations (Scopus)

Abstract

Haloperidol augmented a trend of an increase in the heat shock protein (hsp70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cortex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administered alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Haloperidol and the atypical antipsychotic drugs may thus have differential effects on hsp70 expression in some brain regions of PCP-treated rats.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalMolecular Brain Research
Volume73
Issue number1-2
DOIs
Publication statusPublished - Nov 10 1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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