TY - JOUR
T1 - Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats
AU - Nakahara, Tatsuo
AU - Kuroki, Toshihide
AU - Hondo, Hisao
AU - Tsutsumi, Tetsuyuki
AU - Fukuda, Kenji
AU - Yao, Hiroshi
AU - Uchimura, Hideyuki
PY - 1999/11/10
Y1 - 1999/11/10
N2 - Haloperidol augmented a trend of an increase in the heat shock protein (hsp70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cortex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administered alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Haloperidol and the atypical antipsychotic drugs may thus have differential effects on hsp70 expression in some brain regions of PCP-treated rats.
AB - Haloperidol augmented a trend of an increase in the heat shock protein (hsp70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cortex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administered alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Haloperidol and the atypical antipsychotic drugs may thus have differential effects on hsp70 expression in some brain regions of PCP-treated rats.
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U2 - 10.1016/S0169-328X(99)00248-X
DO - 10.1016/S0169-328X(99)00248-X
M3 - Article
C2 - 10581414
AN - SCOPUS:0032726604
SN - 0006-8993
VL - 73
SP - 193
EP - 197
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -