Effects of augmenting cardiac contractility, preload, and heart rate on cardiac output during enflurane anesthesia

M. Sato, S. Hoka, H. Arimura, K. Ono, J. Yoshitake

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (E(max)). Dobutamine (3, 6, and 9 μg·kg-1·min-1) was administered to augment cardiac contractility. Autologous blood (5.0 and 10 mL/kg) was infused to increase preload. Atrial pacing was used to increase the heart rate by about 30%. Cardiac output decreased from 96 ± 4 (0% enflurane) (mean ± SE) to 73 ± 5 (1.7% enflurane) and to 46 ± 7 mL·kg-1·min-1 (3.4% enflurane), concomitantly with decreases in E(max) from 6.0 ± 1.2 (0% enflurane) to 4.5 ± 1.2 (1.7% enflurane) and to 2.5 ± 0.5 mm Hg/mL (3.4% enflurane). Dobutamine (3, 6, and 9 μg·kg-1·min-1) increased E(max) from 69% ± 7% (compared to 0% enflurane with no dobutamine) to 139% ± 15%, 167% ± 25%, and 183% ± 35% at 1.7% enflurane, and from 43% ± 8% to 78% ± 7%, 137% ± 20%, and 157% ± 22% at 3.4% enflurane, respectively. The decreases in cardiac output by 1.7% and 3.4% enflurane were reversed by the intravenous administration of 3 μg·kg-1·min-1 of dobutamine. Cardiac output was significantly increased by administration of 10 mL/kg of autologous blood at 1.7% enflurane, but did not significantly increase at 3.4% enflurane. Increasing the heart rate did not significantly increase cardiac output at 1.7% and 3.4% enflurane. The results of this study suggest that increasing cardiac contractility is the most effective therapeutic means of reversing circulatory depression during enflurane anesthesia.

Original languageEnglish
Pages (from-to)590-596
Number of pages7
JournalAnesthesia and Analgesia
Volume73
Issue number5
Publication statusPublished - Jan 1 1991

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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