Effects of behavior therapy on regional cerebral blood flow in obsessive-compulsive disorder

Eriko Nakatani, Akiko Nakgawa, Yoko Ohara, Shoko Goto, Naruhiko Uozumi, Michiyo Iwakiri, Yukari Yamamoto, Keisuke Motomura, Yasuro Iikura, Toshiko Yamagami

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)


Very few functional neuroimaging studies have been performed on patients with obsessive-compulsive disorder (OCD) undergoing behavior therapy, even though it is recognized to be an effective treatment for this disorder. We measured the regional cerebral blood flow (rCBF) using the Xenon inhalation method in 31 treatment-refractory patients with OCD and the same number of age-matched normal controls. We also studied changes in rCBF in 22 OCD patients who had demonstrated a significant improvement after the behavior therapy. The OCD patients showed a significant bilateral elevation in the rCBF in the basal ganglia compared with the normal controls. After successful treatment, a significant decrease was found in the rCBF in the right head of the caudate nucleus that tended to correlate with clinical improvement.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalPsychiatry Research - Neuroimaging
Issue number2
Publication statusPublished - Oct 30 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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