Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain

K. Etou, Toshihide Kuroki, Y. Tatebayashi, N. Tashiro, M. Hirano

Research output: Contribution to journalArticle

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Abstract

To elucidate the psychotropic actions of calcium (Ca) antagonists, we investigated the effect of the voltage-dependent Ca channel antagonists, nifedipine and flunarizine, on phencyclidine (PCP)-induced changes in the monoamine metabolism in the regional brain areas of rats. The results indicate that the administration of nifedipine alone attenuated dopamine (DA) metabolism in the nucleus caudatus putamen while enhancing serotonin (5-HT) metabolism. By contrast, flunarizine increased DA metabolism. PCP significantly increased DA metabolite levels in the pre frontal cortex, the nucleus caudatus putamen, and the amygdala. The PCP-induced increases in DA metabolism in these regions were significantly antagonized by nifedipine, but not by flunarizine. These results indicate that nifedipine attenuates the PCP-induced hyperactivity of the dopaminergic neurons, suggesting antipsychotic properties for this drug.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalBiochemical Pharmacology
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 12 1996

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Flunarizine
Phencyclidine
Nifedipine
Metabolism
Rats
Brain
Calcium
Dopamine
Caudate Nucleus
Putamen
Serotonin
Dopaminergic Neurons
Calcium Channel Blockers
Frontal Lobe
Calcium Channels
Metabolites
Amygdala
Antipsychotic Agents
Neurons

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

Cite this

Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain. / Etou, K.; Kuroki, Toshihide; Tatebayashi, Y.; Tashiro, N.; Hirano, M.

In: Biochemical Pharmacology, Vol. 51, No. 1, 12.01.1996, p. 83-86.

Research output: Contribution to journalArticle

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