Effects of Captopril on Forearm Oxygen Consumption during Dynamic Handgrip Exercise in Patients with Congestive Heart Failure

Imaizumi Tsutomu, Takeshita Akira, Nakamura Naonori, Sakai Kikuo, Hirooka Yoshitaka, Suzuki Satoshi, Yoshida Megumu, Nakamura Motoomi

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Abstract

The maximal exercise capacity of patients with congestive heart failure (GHF) is frequently decreased because of decreased skeletal muscle oxygen utilization. In this study we examined whether forearm oxygen utilization is decreased during dynamic handgrip exercise in patients with CHF and whether captopril improves forearm oxygen utilization. They were divided into 3 groups according to the level of plasma renin activity (PRA) and New York Heart Association functional classification (NYHA): Group 1 consisted of 7 normal (control) subjects (PRA: 0.5±0.2 ng/ml/h, NYHA: 0); Group 2, 7 patients with severe CHF (PRA: 11.3±3.9 ng/ml/h, NYHA: 3.6±0.3); Group 3, 4 patients with mild CHF (PRA: 2.4+0.2 ng/ml/h, NYHA: 2 + 0). Forearm blood flow was measured by a strain gauge plethysmograph at rest and during dynamic handgrip exercise. Regional arterial venous oxygen content was measured and forearm oxygen consumption was calculated by the Fick principle. Forearm blood flow was less (p<0.05) at rest and during exercise in patients with severe CHF than in control subjects; this was compensated for by increased oxygen extraction, thus maintaining forearm oxygen consumption at a normal level at rest and during submaximal exercise. During maximal exercise, oxygen extraction was not different between normal control subjects and patients with severe CHF, thus forearm oxygen consumption was significantly less (p<0.01) in patients with severe CHF than in control subjects. In patients with mild CHF, forearm blood flow, oxygen extraction and oxygen consumption were not different from those in normal control subjects. Captopril (25 mg orally) did not alter forearm hemodynamics at rest and during exercise in control subjects and patients with mild CHF. In patients with severe CHF, captopril lowered systolic and mean blood pressure.

Original languageEnglish
Pages (from-to)817-828
Number of pages12
Journaljapanese heart journal
Volume31
Issue number6
DOIs
Publication statusPublished - 1990

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Tsutomu, I., Akira, T., Naonori, N., Kikuo, S., Yoshitaka, H., Satoshi, S., Megumu, Y., & Motoomi, N. (1990). Effects of Captopril on Forearm Oxygen Consumption during Dynamic Handgrip Exercise in Patients with Congestive Heart Failure. japanese heart journal, 31(6), 817-828. https://doi.org/10.1536/ihj.31.817