Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa; S. Kakehata; N. Akaike; S. Komune; T. Takasaka; T. Uemura

doi:10.1016/0006-8993(92)90966-D

Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

Surgery

Research output: Contribution to journal › Article

29 Citations (Scopus)

Abstract

The effects of various Ca²⁺ antagonists and aminoglycoside antibiotics on the Ca²⁺ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La³⁺ ≫ Cd²⁺ ≫ Ni²⁺ ≫ Co²⁺ for inorganic Ca²⁺ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca²⁺ channel.

Original language	English
Pages (from-to)	345-347
Number of pages	3
Journal	Brain Research
Volume	580
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)90966-D
Publication status	Published - May 15 1992

Fingerprint

Outer Auditory Hair Cells

Cochlea

Aminoglycosides

Guinea Pigs

Conotoxins

Flunarizine

Anti-Bacterial Agents

Nicardipine

Diltiazem

Amiloride

Patch-Clamp Techniques

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Cite this

Nakagawa, T., Kakehata, S., Akaike, N., Komune, S., Takasaka, T., & Uemura, T. (1992). Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea. Brain Research, 580(1-2), 345-347. https://doi.org/10.1016/0006-8993(92)90966-D

Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea. / Nakagawa, T.; Kakehata, S.; Akaike, N.; Komune, S.; Takasaka, T.; Uemura, T.

In: Brain Research, Vol. 580, No. 1-2, 15.05.1992, p. 345-347.

Research output: Contribution to journal › Article

Nakagawa, T, Kakehata, S, Akaike, N, Komune, S, Takasaka, T & Uemura, T 1992, 'Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea', Brain Research, vol. 580, no. 1-2, pp. 345-347. https://doi.org/10.1016/0006-8993(92)90966-D

Nakagawa T, Kakehata S, Akaike N, Komune S, Takasaka T, Uemura T. Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea. Brain Research. 1992 May 15;580(1-2):345-347. https://doi.org/10.1016/0006-8993(92)90966-D

Nakagawa, T. ; Kakehata, S. ; Akaike, N. ; Komune, S. ; Takasaka, T. ; Uemura, T. / Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea. In: Brain Research. 1992 ; Vol. 580, No. 1-2. pp. 345-347.

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10.1016/0006-8993(92)90966-D