Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa; S. Kakehata; N. Akaike; S. Komune; T. Takasaka; T. Uemura

doi:10.1016/0006-8993(92)90966-D

Effects of Ca²⁺ antagonists and aminoglycoside antibiotics on Ca²⁺ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

Surgery

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Abstract

The effects of various Ca²⁺ antagonists and aminoglycoside antibiotics on the Ca²⁺ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La³⁺ ≫ Cd²⁺ ≫ Ni²⁺ ≫ Co²⁺ for inorganic Ca²⁺ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca²⁺ channel.

Original language	English
Pages (from-to)	345-347
Number of pages	3
Journal	Brain Research
Volume	580
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)90966-D
Publication status	Published - May 15 1992

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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abstract = "The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ ≫ Cd2+ ≫ Ni2+ ≫ Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.",

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T1 - Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea

AU - Nakagawa, T.

AU - Kakehata, S.

AU - Akaike, N.

AU - Komune, S.

AU - Takasaka, T.

AU - Uemura, T.

PY - 1992/5/15

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