TY - JOUR
T1 - Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea
AU - Nakagawa, T.
AU - Kakehata, S.
AU - Akaike, N.
AU - Komune, S.
AU - Takasaka, T.
AU - Uemura, T.
N1 - Funding Information:
This study was supported by Grant-in-Aid for Scientific Research Nos. 02241101, 02304031, and 0330426 from The Ministry of Education, Science and Culture, Japan, and a Fund from the Institute of Space and Astronautical Science (U-8) to N.A.
PY - 1992/5/15
Y1 - 1992/5/15
N2 - The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ ≫ Cd2+ ≫ Ni2+ ≫ Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.
AB - The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ ≫ Cd2+ ≫ Ni2+ ≫ Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.
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U2 - 10.1016/0006-8993(92)90966-D
DO - 10.1016/0006-8993(92)90966-D
M3 - Article
C2 - 1504812
AN - SCOPUS:0026611594
VL - 580
SP - 345
EP - 347
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -