Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ ≫ Cd2+ ≫ Ni2+ ≫ Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.

Original languageEnglish
Pages (from-to)345-347
Number of pages3
JournalBrain Research
Volume580
Issue number1-2
DOIs
Publication statusPublished - May 15 1992

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Outer Auditory Hair Cells
Cochlea
Aminoglycosides
Guinea Pigs
Conotoxins
Flunarizine
Anti-Bacterial Agents
Nicardipine
Diltiazem
Amiloride
Patch-Clamp Techniques

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea. / Nakagawa, T.; Kakehata, S.; Akaike, N.; Komune, S.; Takasaka, T.; Uemura, T.

In: Brain Research, Vol. 580, No. 1-2, 15.05.1992, p. 345-347.

Research output: Contribution to journalArticle

Nakagawa, T. ; Kakehata, S. ; Akaike, N. ; Komune, S. ; Takasaka, T. ; Uemura, T. / Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea. In: Brain Research. 1992 ; Vol. 580, No. 1-2. pp. 345-347.
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