Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats

Toshihiko Katafuchi, Yutaka Oomura, Mieko Kurosawa

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The effects of stimulation of the hypothalamic paraventricular nucleus (PVN) by l-glutamate on blood pressure and ongoing activities of adrenal and renal sympathetic nerves were examined in anesthetized rats. Microinjection of excitatory amino acid, l-glutamate (100 nmol in 200 nl saline), into the unilateral PVN resulted in an increase in the ipsilateral adrenal nerve activity, while it resulted in decreases in renal nerve activity and arterial blood pressure. After severance of bilateral carotid sinus and vagal nerves, the decreased response of blood pressure to the same stimulus did not change, while the decreased response of renal nerve activity was almost abolished, and the increased response of adrenal nerve activity still remained, though it slightly attenuated. The involvements of baroreceptor afferents and vagal afferents in these responses were discussed.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalNeuroscience Letters
Volume86
Issue number2
DOIs
Publication statusPublished - Mar 31 1988

Fingerprint

Chemical Stimulation
Paraventricular Hypothalamic Nucleus
Kidney
Glutamic Acid
Blood Pressure
Carotid Sinus
Excitatory Amino Acids
Pressoreceptors
Microinjections
Arterial Pressure

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats. / Katafuchi, Toshihiko; Oomura, Yutaka; Kurosawa, Mieko.

In: Neuroscience Letters, Vol. 86, No. 2, 31.03.1988, p. 195-200.

Research output: Contribution to journalArticle

Katafuchi, Toshihiko ; Oomura, Yutaka ; Kurosawa, Mieko. / Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats. In: Neuroscience Letters. 1988 ; Vol. 86, No. 2. pp. 195-200.
@article{1b2cb2ff63ea482caeae8dc649c0b2d1,
title = "Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats",
abstract = "The effects of stimulation of the hypothalamic paraventricular nucleus (PVN) by l-glutamate on blood pressure and ongoing activities of adrenal and renal sympathetic nerves were examined in anesthetized rats. Microinjection of excitatory amino acid, l-glutamate (100 nmol in 200 nl saline), into the unilateral PVN resulted in an increase in the ipsilateral adrenal nerve activity, while it resulted in decreases in renal nerve activity and arterial blood pressure. After severance of bilateral carotid sinus and vagal nerves, the decreased response of blood pressure to the same stimulus did not change, while the decreased response of renal nerve activity was almost abolished, and the increased response of adrenal nerve activity still remained, though it slightly attenuated. The involvements of baroreceptor afferents and vagal afferents in these responses were discussed.",
author = "Toshihiko Katafuchi and Yutaka Oomura and Mieko Kurosawa",
year = "1988",
month = "3",
day = "31",
doi = "10.1016/0304-3940(88)90570-8",
language = "English",
volume = "86",
pages = "195--200",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats

AU - Katafuchi, Toshihiko

AU - Oomura, Yutaka

AU - Kurosawa, Mieko

PY - 1988/3/31

Y1 - 1988/3/31

N2 - The effects of stimulation of the hypothalamic paraventricular nucleus (PVN) by l-glutamate on blood pressure and ongoing activities of adrenal and renal sympathetic nerves were examined in anesthetized rats. Microinjection of excitatory amino acid, l-glutamate (100 nmol in 200 nl saline), into the unilateral PVN resulted in an increase in the ipsilateral adrenal nerve activity, while it resulted in decreases in renal nerve activity and arterial blood pressure. After severance of bilateral carotid sinus and vagal nerves, the decreased response of blood pressure to the same stimulus did not change, while the decreased response of renal nerve activity was almost abolished, and the increased response of adrenal nerve activity still remained, though it slightly attenuated. The involvements of baroreceptor afferents and vagal afferents in these responses were discussed.

AB - The effects of stimulation of the hypothalamic paraventricular nucleus (PVN) by l-glutamate on blood pressure and ongoing activities of adrenal and renal sympathetic nerves were examined in anesthetized rats. Microinjection of excitatory amino acid, l-glutamate (100 nmol in 200 nl saline), into the unilateral PVN resulted in an increase in the ipsilateral adrenal nerve activity, while it resulted in decreases in renal nerve activity and arterial blood pressure. After severance of bilateral carotid sinus and vagal nerves, the decreased response of blood pressure to the same stimulus did not change, while the decreased response of renal nerve activity was almost abolished, and the increased response of adrenal nerve activity still remained, though it slightly attenuated. The involvements of baroreceptor afferents and vagal afferents in these responses were discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023851807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023851807&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(88)90570-8

DO - 10.1016/0304-3940(88)90570-8

M3 - Article

C2 - 2897095

AN - SCOPUS:0023851807

VL - 86

SP - 195

EP - 200

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -