TY - JOUR
T1 - Effects of conditioning intensity in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia
AU - Takashima, Shuichiro
AU - Miyamoto, Toshihiro
AU - Kamimura, Tomohiko
AU - Yoshimoto, Goichi
AU - Yoshida, Shuro
AU - Henzan, Hideho
AU - Takase, Ken
AU - Kato, Koji
AU - Ito, Yoshikiyo
AU - Ohno, Yuju
AU - Nagafuji, Koji
AU - Eto, Tetsuya
AU - Teshima, Takanori
AU - Akashi, Koichi
N1 - Funding Information:
We appreciate the medical and nursing staff working on Kyushu University Hospital and participating hospitals. This work was supported by JSPS KAKENHI (23390254, 24659462 to T.M.).
Publisher Copyright:
© 2015, The Japanese Society of Hematology.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We retrospectively analyzed the outcomes of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent first allogeneic stem cell transplantation (allo-SCT) at complete remission (CR) with myeloablative conditioning (MAC, n = 31) or reduced-intensity conditioning (RIC, n = 15) between 2001 and 2012. All the patients had received tyrosine kinase inhibitor (TKI)-based chemotherapy prior to allo-SCT. Overall survival (OS) rates (57 vs 63 %, p = 0.53), leukemia-free survival rates (50 vs 65 %, p = 0.29), and non-relapse mortality rates (39 vs 35 %, p = 0.62) at 2 years were similar between the MAC and RIC groups. The minimal residual disease (MRD) status evaluated by sensitive polymerase chain reaction prior to allo-SCT did not influence the OS rate (77 vs 54 %, p = 0.28) and leukemia-free survival rate (69 vs 51 %, p = 0.48), irrespective of the conditioning intensity. Our data suggest that the RIC regimen may represent a sufficient intensity of therapeutic pre-transplant conditioning for patients with Ph+ALL who have maintained a hematological CR with TKI-combined chemotherapy.
AB - We retrospectively analyzed the outcomes of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent first allogeneic stem cell transplantation (allo-SCT) at complete remission (CR) with myeloablative conditioning (MAC, n = 31) or reduced-intensity conditioning (RIC, n = 15) between 2001 and 2012. All the patients had received tyrosine kinase inhibitor (TKI)-based chemotherapy prior to allo-SCT. Overall survival (OS) rates (57 vs 63 %, p = 0.53), leukemia-free survival rates (50 vs 65 %, p = 0.29), and non-relapse mortality rates (39 vs 35 %, p = 0.62) at 2 years were similar between the MAC and RIC groups. The minimal residual disease (MRD) status evaluated by sensitive polymerase chain reaction prior to allo-SCT did not influence the OS rate (77 vs 54 %, p = 0.28) and leukemia-free survival rate (69 vs 51 %, p = 0.48), irrespective of the conditioning intensity. Our data suggest that the RIC regimen may represent a sufficient intensity of therapeutic pre-transplant conditioning for patients with Ph+ALL who have maintained a hematological CR with TKI-combined chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=84949102205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949102205&partnerID=8YFLogxK
U2 - 10.1007/s12185-015-1883-0
DO - 10.1007/s12185-015-1883-0
M3 - Article
C2 - 26475283
AN - SCOPUS:84949102205
SN - 0925-5710
VL - 102
SP - 689
EP - 696
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 6
ER -