Effects of cyclosporin A on the development of osteonecrosis in rabbits

Keita Miyanishi, Takuaki Yamamoto, Takahiko Irisa, Akihisa Yamashita, Goro Motomura, Seiya Jingushi, Yukihide Iwamoto

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Abstract

Background: Osteonecrosis (ON) of the femoral head is a serious complication in patients who have undergone organ transplantation. Introduction of cyclosporin A has resulted in lower-dosage steroid treatment and a decrease in the occurrence of ON. We examined the effect of cyclosporin A on the development of ON in rabbits. Methods: In experiment A, rabbits were given cyclosporin A and 20 mg/kg methylprednisolone acetate. The control group was given 20 mg/kg methylprednisolone acetate only. Experiment B was then performed to mimic the clinical situation in which the use of cyclosporin A and lower steroid doses resulted in a decrease in occurrence of ON. In Experiment C, the effects of treatment with cyclosporin A only on development of ON were examined. 4 weeks after injection, bilateral femora and humeri were examined histopathologically for ON. Results: Cyclosporin A increased the incidence of ON in rabbits when given in combination with steroid (p = 0.04). No ON lesions were observed in rabbits treated with cyclosporin A alone. Interpretation: Our findings suggest that the clinically reported reduction in occurrence of ON following the use of cyclosporin A is probably attributable to the lower steroid doses used. Copyright

Original languageEnglish
Pages (from-to)813-819
Number of pages7
JournalActa Orthopaedica
Volume77
Issue number5
DOIs
Publication statusPublished - Oct 1 2006

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

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    Miyanishi, K., Yamamoto, T., Irisa, T., Yamashita, A., Motomura, G., Jingushi, S., & Iwamoto, Y. (2006). Effects of cyclosporin A on the development of osteonecrosis in rabbits. Acta Orthopaedica, 77(5), 813-819. https://doi.org/10.1080/17453670610013042