Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy: a Prospective Randomized Trial

Yusuke Akamaru, Tsuyoshi Takahashi, Toshirou Nishida, Takeshi Omori, Kazuhiro Nishikawa, Shoki Mikata, Noriyuki Yamamura, Satoru Miyazaki, Hiroshi Noro, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Purpose: This study aimed to assess the efficacy of daikenchuto (DKT), a commonly prescribed, traditional Japanese herbal medicine, on postoperative intestinal dysfunction after gastric cancer surgery.

Results: During the hospital stay, significant differences were observed between the DKT group and controls in the number of stools per day (1.1 ± 0.6 vs 0.8 ± 0.4, respectively; P = 0.037) and stool consistencies (Bristol scale ratings were 3.7 ± 0.8 vs 3.1 ± 0.8, respectively; P = 0.041). The DKT group showed significant reductions in gas volume scores, calculated from abdominal radiographs, at 7 days, 1 month, and 3 months after surgery. The groups did not show significant differences in quality of life scores (based on the Gastrointestinal Symptom Rating Scale) or in the incidence of postoperative ileus.

Methods: Patients with gastric cancer scheduled for a total gastrectomy were randomly assigned before surgery to receive either no treatment (n = 40; control group) or DKT (7.5 g/day, t.i.d.) for 3 months (n = 41) postoperatively. We examined gastrointestinal motility, stool attributes, the quantity of bowel gas, the quality of life, and the incidence of postoperative ileus.

Conclusion: DKT improved bowel movements, stool properties, and bowel gas. These results suggested that DKT promoted early postoperative bowel functions after total gastrectomy.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

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